Blagov Alexander, Bukrinsky Michael, Utkina Aleksandra, Babayeva Gulalek, Sukhorukov Vasily, Orekhov Alexander
Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Moscow, 125315, Russia.
School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA.
Biocell. 2025;49(7):1135-1140. doi: 10.32604/biocell.2025.062821. Epub 2025 Jul 25.
Eosinophils are multifunctional granulocytes that contribute to the initiation and modulation of inflammation. Accumulating evidence suggests that eosinophils are adaptable leukocytes that orchestrate the resolution of inflammatory responses. The most prevalent chronic inflammatory illness, rheumatoid arthritis (RA), is typified by persistent synovitis that makes it hard for the disease to go away on its own. Interestingly, a unique subset of eosinophils known as regulatory eosinophils has been found in RA patients' synovium, especially while the disease is in remission. Pro-resolving signatures of regulatory eosinophils in the synovium are distinct from those of their lung counterparts. The most recent research on eosinophils and their function in this disease pathogenesis is compiled in this review. Based on the role of regulatory eosinophils, a new pathological model of inflammation resolution in RA is proposed, and potential therapeutic strategies aimed at enhancing the action of regulatory eosinophils in RA are proposed.
嗜酸性粒细胞是多功能粒细胞，参与炎症的启动和调节。越来越多的证据表明，嗜酸性粒细胞是可调节的白细胞，可协调炎症反应的消退。最常见的慢性炎症性疾病类风湿性关节炎（RA）的典型特征是持续性滑膜炎，这使得疾病难以自行消退。有趣的是，在RA患者的滑膜中发现了一种独特的嗜酸性粒细胞亚群，称为调节性嗜酸性粒细胞，尤其是在疾病缓解期。滑膜中调节性嗜酸性粒细胞的促消退特征与其肺部对应细胞不同。本综述汇编了关于嗜酸性粒细胞及其在该疾病发病机制中的作用的最新研究。基于调节性嗜酸性粒细胞的作用，提出了RA炎症消退的新病理模型，并提出了旨在增强调节性嗜酸性粒细胞在RA中作用的潜在治疗策略。
