Zheng Baohua, Huang Zhicheng, Wang Zhiwei, Du Junhao, Jiang Junhui, Xiao Chunhong, Wang Yu
Department of General Surgery, Fuzong Teaching Hospital of Fujian University of Traditional Chinese Medicine (900th Hospital), Fuzhou, China.
Department of General Surgery, Dongfang Hospital of Xiamen University, School of Medicine, Xiamen University, Fuzhou, China.
Front Nutr. 2025 Jul 25;12:1586569. doi: 10.3389/fnut.2025.1586569. eCollection 2025.
BACKGROUND: Given the growing interest in gut health, particularly in the context of irritable bowel syndrome (IBS), this study investigates the potential effects of dietary creatine intake on measures of gut health. Additionally, in response to anecdotal reports on the internet that have not been corroborated by clinical trials, this research examines the relationship between creatine consumption and gastrointestinal outcomes, aiming to address the existing knowledge gap in this area. METHODS: This study utilized data from the 2005-2010 National Health and Nutrition Examination Survey (NHANES). Multivariable logistic regression and subgroup analyses were conducted to examine the association between dietary creatine intake and the risk of diarrhea and constipation. Additionally, restricted cubic spline (RCS) analysis was employed to assess potential nonlinear relationships. RESULTS: In the fully adjusted model, each one-unit increase in the log-transformed 2-day average dietary creatine intake-equivalent to a tenfold increase in absolute intake-was associated with a 19% lower risk of chronic constipation (adjusted OR = 0.81, 95% CI: 0.65-0.96, = 0.015). However, no significant association was found between dietary creatine intake and chronic diarrhea (adjusted OR = 1.04, 95% CI: 0.87-1.36, = 0.421). The protective effect of higher dietary creatine intake against chronic constipation was more pronounced in males (adjusted OR = 0.77, 95% CI: 0.66-0.89, < 0.001), younger individuals (adjusted OR = 0.89, 95% CI: 0.79 ∼ 0.99, = 0.047)), and participants without cardiovascular disease (adjusted OR = 0.91, 95% CI: 0.83 ∼ 0.99, = 0.047). RCS analysis confirmed a linear relationship between 2-day average dietary creatine intake and the risk of chronic constipation after adjusting for confounding variables. CONCLUSION: Higher dietary creatine intake may offer protective benefits against chronic constipation, particularly in specific subgroups, while showing no significant association with chronic diarrhea. Further large-scale studies are warranted to clarify creatine's role in gastrointestinal health. These findings highlight the potential of creatine as a dietary factor in promoting gut health.
背景：鉴于人们对肠道健康的兴趣日益浓厚，尤其是在肠易激综合征（IBS）的背景下，本研究调查了饮食中摄入肌酸对肠道健康指标的潜在影响。此外，针对互联网上未经临床试验证实的传闻报道，本研究考察了肌酸摄入量与胃肠道结局之间的关系，旨在填补该领域现有的知识空白。 方法：本研究利用了2005 - 2010年美国国家健康和营养检查调查（NHANES）的数据。进行多变量逻辑回归和亚组分析，以检验饮食中肌酸摄入量与腹泻和便秘风险之间的关联。此外，采用受限立方样条（RCS）分析来评估潜在的非线性关系。 结果：在完全调整模型中，经对数转换的2天平均饮食肌酸摄入量每增加一个单位——相当于绝对摄入量增加10倍——与慢性便秘风险降低19%相关（调整后的比值比[OR] = 0.81，95%置信区间[CI]：0.65 - 0.96，P = 0.015）。然而，未发现饮食中肌酸摄入量与慢性腹泻之间存在显著关联（调整后的OR = 1.04，95% CI：0.87 - 1.36，P = 0.421）。较高的饮食肌酸摄入量对慢性便秘的保护作用在男性（调整后的OR = 0.77，95% CI：0.66 - 0.89，P < 0.001）、较年轻个体（调整后的OR = 0.89，95% CI：0.79 ∼ 0.99，P = 0.047）以及无心血管疾病的参与者（调整后的OR = 0.91，95% CI：0.83 ∼ 0.99，P = 0.047）中更为明显。RCS分析在调整混杂变量后证实了2天平均饮食肌酸摄入量与慢性便秘风险之间存在线性关系。 结论：较高的饮食肌酸摄入量可能对慢性便秘具有保护作用，尤其是在特定亚组中，而与慢性腹泻无显著关联。有必要进行进一步的大规模研究以阐明肌酸在胃肠道健康中的作用。这些发现凸显了肌酸作为促进肠道健康的饮食因素的潜力。
Cochrane Database Syst Rev. 2016-8-22
Cochrane Database Syst Rev. 2022-2-24
Cochrane Database Syst Rev. 2017-3-23
Cochrane Database Syst Rev. 2013-12-18
Gut Microbes. 2023
Eur J Clin Invest. 2022-11
Zotero 插件