Harishkumar M, Choudhary B Mohan, Ganesh Arjun, Lourdes Kevin
Department of Orthopaedic Surgery, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
J Orthop Case Rep. 2025 Aug;15(8):158-163. doi: 10.13107/jocr.2025.v15.i08.5924.
Giant cell tumor (GCT) of bone is a benign but locally aggressive neoplasm, commonly affecting the epiphysio-metaphyseal regions of long bones in young adults. The proximal tibia is among the most frequent sites. Management is challenging due to the tumors high recurrence potential and its location near weight-bearing joints.
A 22-year-old female presented with a 5-month history of pain and swelling over the right knee. Imaging revealed an epiphysio-metaphyseal osteolytic lesion in the proximal tibia with an anterior cortical breach, confirmed on computed tomography and magnetic resonance imaging. Surgical management included extended intralesional curettage through an anteromedial approach. The tumor cavity was treated with high-speed burr, hydrogen peroxide lavage to prevent local recurrence and filled the cavity using sandwich technique with polymethyl methacrylate bone cement and gel foam.
Post-operative recovery was better. The patient was started on partial weight-bearing in 1 week and full weight-bearing by 2 weeks. Patient achieved nearly the full range of movements at the knee by 8 weeks. Histopathology confirmed the diagnosis of GCT. At 1-year follow-up, the patient showed no clinical or radiological signs of recurrence, with an excellent functional outcome.
Extended curettage with adjuvant therapy and bone cementing through the sandwich technique offers a joint-preserving and effective treatment for GCTs of the proximal tibia, even in the presence of cortical breach. A long-term follow-up is essential to monitor for local recurrence or pulmonary metastasis.
骨巨细胞瘤(GCT)是一种良性但具有局部侵袭性的肿瘤,常见于年轻成年人长骨的骨骺-干骺端区域。胫骨近端是最常见的发病部位之一。由于该肿瘤具有较高的复发潜力且位于负重关节附近,其治疗具有挑战性。
一名22岁女性,右膝疼痛肿胀5个月。影像学检查显示胫骨近端骨骺-干骺端溶骨性病变,伴有前侧皮质破坏,计算机断层扫描和磁共振成像证实了这一情况。手术治疗包括通过前内侧入路进行扩大的病灶内刮除术。使用高速磨钻处理肿瘤腔,用过氧化氢冲洗以防止局部复发,并采用三明治技术用聚甲基丙烯酸甲酯骨水泥和明胶海绵填充腔隙。
术后恢复较好。患者术后1周开始部分负重,2周时完全负重。8周时患者膝关节活动范围几乎恢复正常。组织病理学确诊为骨巨细胞瘤。随访1年,患者无临床或影像学复发迹象,功能预后良好。
扩大刮除术联合辅助治疗及通过三明治技术进行骨水泥填充,即使在存在皮质破坏的情况下,也为胫骨近端骨巨细胞瘤提供了一种保留关节且有效的治疗方法。长期随访对于监测局部复发或肺转移至关重要。