Saibaba Balaji, Chouhan Devendra Kumar, Kumar Vishal, Dhillon Mandeep Singh, Rajoli Sreekanth Reddy
Department of Orthopaedics, Post Graduate Institute of Medical Education & Research, Chandigarh, India.
J Orthop Surg (Hong Kong). 2014 Dec;22(3):351-5. doi: 10.1177/230949901402200317.
To evaluate outcomes of 36 patients who underwent curettage, use of phenol, and reconstruction using the sandwich technique for giant cell tumour (GCT) of bone around the knee.
22 women and 14 men aged 19 to 46 (mean, 29.6) years underwent intralesional curettage, use of phenol, and reconstruction using the sandwich technique for GCT of the proximal tibia (n=23) or distal femur (n=13). Two of the cases were recurrences. Two, 18, and 16 tumours were classified as grade I, grade II, and grade III, respectively. Five of the grade III tumours were associated with an extra-articular pathological fracture. Patients underwent intralesional curettage, use of phenol, and reconstruction with allograft, gel foam, and cement (the sandwich technique). Pathological fractures were fixed with plates. Functional outcome was evaluated using the Musculoskeletal Tumor Society (MSTS) score.
The mean follow-up period was 5 (2.5-11) years. The mean MSTS score was 27.7 out of 30 (standard deviation, 3; range, 16-30). One patient with a grade III tumour in the proximal tibia had a recurrence detected elsewhere after 3 years. Her MSTS score at 2 years was 26. No patient had malignant transformation.
Intralesional curettage, use of phenol, and reconstruction with allograft, gel foam, and cement (the sandwich technique) for GCT of bone achieved good functional outcome and a low recurrence rate.
评估36例接受刮除术、苯酚应用及采用三明治技术重建治疗膝关节周围骨巨细胞瘤(GCT)患者的治疗效果。
22例女性和14例男性,年龄19至46岁(平均29.6岁),因胫骨近端(n = 23)或股骨远端(n = 13)的GCT接受病灶内刮除术、苯酚应用及采用三明治技术重建。其中2例为复发病例。2例、18例和16例肿瘤分别被分类为I级、II级和III级。III级肿瘤中有5例伴有关节外病理性骨折。患者接受病灶内刮除术、苯酚应用,并用同种异体骨、明胶海绵和骨水泥进行重建(三明治技术)。病理性骨折用钢板固定。使用肌肉骨骼肿瘤学会(MSTS)评分评估功能结果。
平均随访期为5年(2.5 - 11年)。MSTS平均评分为27.7分(满分30分,标准差3分;范围16 - 30分)。1例胫骨近端III级肿瘤患者在3年后于其他部位复发。其2年时的MSTS评分为26分。无患者发生恶性转化。
病灶内刮除术、苯酚应用及用同种异体骨、明胶海绵和骨水泥进行重建(三明治技术)治疗骨GCT可取得良好的功能效果和较低的复发率。