Kriebel D, Henry J, Gold J C, Bronsdon A, Commoner B
J Environ Pathol Toxicol Oncol. 1985 Nov-Dec;6(2):157-69.
Using the methods of Yamasaki and Ames (1977), we have studied the mutagenicity of urine samples from 29 cigarette smokers and 14 nonsmokers. Duplicate plates at each dose yield reproducible dose-response curves, evening and 24-hour samples of smokers' urine have similar levels of mutagenic activity, as do evening samples from the same smoker from different days. Smokers' daily cigarette tar intake is correlated with urinary mutagen concentration, but the correlation achieves statistical significance only in the sub-sample of smokers over 25 years old. Mutagenic activity is also detectable in some nonsmokers, but as a group, their urinary mutagenic activity is far lower than that of smokers.
采用山崎和艾姆斯（1977年）的方法，我们研究了29名吸烟者和14名不吸烟者尿液样本的致突变性。每个剂量的重复平板产生可重复的剂量反应曲线，吸烟者尿液的夜间和24小时样本具有相似的致突变活性水平，来自同一吸烟者不同日期的夜间样本也是如此。吸烟者每日香烟焦油摄入量与尿液诱变剂浓度相关，但这种相关性仅在25岁以上吸烟者的子样本中具有统计学意义。在一些不吸烟者中也可检测到致突变活性，但作为一个群体，他们的尿液致突变活性远低于吸烟者。
