• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

New onset hidradenitis suppurativa and eruptive milia associated with gamma secretase inhibitor therapy in a patient with desmoid tumor: A case report.

作者信息

Gutierrez Yasmin, DeClerck Brittney, Hsiao Jennifer L, Lee Katrina H

机构信息

Department of Dermatology, University of Southern California, Keck School of Medicine, Los Angeles, California.

出版信息

JAAD Case Rep. 2025 Jul 5;63:81-83. doi: 10.1016/j.jdcr.2025.05.042. eCollection 2025 Sep.

DOI:10.1016/j.jdcr.2025.05.042
PMID:40787063
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12329538/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c5e/12329538/9b387e4603ce/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c5e/12329538/e9a17854e663/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c5e/12329538/9b387e4603ce/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c5e/12329538/e9a17854e663/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c5e/12329538/9b387e4603ce/gr2.jpg

相似文献

1
New onset hidradenitis suppurativa and eruptive milia associated with gamma secretase inhibitor therapy in a patient with desmoid tumor: A case report.一名硬纤维瘤患者在接受γ-分泌酶抑制剂治疗后出现新发化脓性汗腺炎和爆发性粟丘疹：病例报告
JAAD Case Rep. 2025 Jul 5;63:81-83. doi: 10.1016/j.jdcr.2025.05.042. eCollection 2025 Sep.
2
Hidradenitis secondary to nirogacestat, a recently approved desmoid tumor medication.尼洛替尼（一种最近获批用于治疗硬纤维瘤的药物）继发的汗腺炎。
JAAD Case Rep. 2024 Dec 31;57:1-2. doi: 10.1016/j.jdcr.2024.12.022. eCollection 2025 Mar.
3
Psychometric validation and interpretation thresholds of the Hidradenitis Suppurativa Quality of Life (HiSQOL©) questionnaire using pooled data from the phase III BE HEARD I & II trials of bimekizumab in hidradenitis suppurativa.使用比美吉珠单抗治疗化脓性汗腺炎的III期BE HEARD I和II试验的汇总数据，对化脓性汗腺炎生活质量（HiSQOL©）问卷进行心理测量学验证和解释阈值分析。
Br J Dermatol. 2025 Jun 20;193(1):93-104. doi: 10.1093/bjd/ljaf067.
4
Validation of the real-world application of the Hidradenitis Suppurativa Quality of Life (HiSQOL) score to adults with hidradenitis suppurativa.化脓性汗腺炎生活质量（HiSQOL）评分在成年化脓性汗腺炎患者真实世界应用中的验证。
Br J Dermatol. 2025 Jan 24;192(2):261-268. doi: 10.1093/bjd/ljae367.
5
A systematic review of Janus kinase inhibitors and spleen tyrosine kinase inhibitors for Hidradenitis suppurativa treatment.一项关于 Janus 激酶抑制剂和脾酪氨酸激酶抑制剂治疗化脓性汗腺炎的系统评价。
Int Immunopharmacol. 2024 Jan 25;127:111435. doi: 10.1016/j.intimp.2023.111435. Epub 2023 Dec 26.
6
Rare missense variants in the SH3 domain of are associated with hidradenitis suppurativa.在 SH3 结构域中罕见的错义变异与化脓性汗腺炎有关。
HGG Adv. 2023 Mar 13;4(2):100187. doi: 10.1016/j.xhgg.2023.100187. eCollection 2023 Apr 13.
7
Efficacy and safety of radiofrequency in the treatment of hidradenitis suppurativa; a systematic review.射频治疗化脓性汗腺炎的疗效和安全性：系统评价。
Lasers Med Sci. 2024 May 25;39(1):139. doi: 10.1007/s10103-024-04077-0.
8
Dermatologic adverse events associated with gamma secretase inhibitor nirogacestat: A retrospective multicenter cohort study.
J Am Acad Dermatol. 2025 Aug 8. doi: 10.1016/j.jaad.2025.08.002.
9
Bimekizumab for the treatment of hidradenitis suppurativa.比美吉珠单抗治疗化脓性汗腺炎。
Immunotherapy. 2024;16(16-17):1005-1013. doi: 10.1080/1750743X.2024.2401308. Epub 2024 Sep 19.
10
Bimekizumab Impact on Patient-Reported Outcomes in Patients with Moderate to Severe Hidradenitis Suppurativa: Pooled 48-Week Results from BE HEARD I&II.比美吉珠单抗对中度至重度化脓性汗腺炎患者报告结局的影响：BE HEARD I&II的48周汇总结果
Dermatol Ther (Heidelb). 2025 Jul 13. doi: 10.1007/s13555-025-01465-4.

本文引用的文献

1
Hidradenitis suppurativa secondary to treatment with a gamma secretase inhibitor.γ-分泌酶抑制剂治疗继发的化脓性汗腺炎。
J Eur Acad Dermatol Venereol. 2024 Mar;38(3):e219-e221. doi: 10.1111/jdv.19544. Epub 2023 Oct 17.
2
Nirogacestat, a γ-Secretase Inhibitor for Desmoid Tumors.尼拉格塞特，一种针对硬纤维瘤的γ-分泌酶抑制剂。
N Engl J Med. 2023 Mar 9;388(10):898-912. doi: 10.1056/NEJMoa2210140.
3
Insights from γ-Secretase: Functional Genetics of Hidradenitis Suppurativa.γ-分泌酶研究新进展：化脓性汗腺炎的功能遗传学研究
J Invest Dermatol. 2021 Aug;141(8):1888-1896. doi: 10.1016/j.jid.2021.01.023. Epub 2021 Apr 7.
4
Hidradenitis suppurativa: Epidemiology, clinical presentation, and pathogenesis.化脓性汗腺炎：流行病学、临床表现和发病机制。
J Am Acad Dermatol. 2020 May;82(5):1045-1058. doi: 10.1016/j.jaad.2019.08.090. Epub 2019 Oct 9.
5
Hidradenitis Suppurativa-Like Lesions Associated with Pharmacologic Inhibition of Gamma-Secretase.与γ-分泌酶的药物抑制相关的化脓性汗腺炎样病变
J Invest Dermatol. 2018 Apr;138(4):979-981. doi: 10.1016/j.jid.2017.09.051. Epub 2017 Nov 11.
6
Safety profile of semagacestat, a gamma-secretase inhibitor: IDENTITY trial findings.γ-分泌酶抑制剂司马吉司他的安全性概况：IDENTITY试验结果
Curr Med Res Opin. 2014 Oct;30(10):2021-32. doi: 10.1185/03007995.2014.939167. Epub 2014 Jul 14.
7
γ-Secretase mutations in hidradenitis suppurativa: new insights into disease pathogenesis.γ-分泌酶突变与化脓性汗腺炎：对疾病发病机制的新认识。
J Invest Dermatol. 2013 Mar;133(3):601-607. doi: 10.1038/jid.2012.372. Epub 2012 Oct 25.
8
gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis.γ-分泌酶通过Notch信号通路发挥作用以维持皮肤附属器，但它们的模式形成或初始形态发生并不需要γ-分泌酶。
Dev Cell. 2004 Nov;7(5):731-43. doi: 10.1016/j.devcel.2004.09.014.