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本文引用的文献

1
Clinical Activity of the γ-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors (Aggressive Fibromatosis).γ-分泌酶抑制剂PF-03084014在患有韧带样瘤（侵袭性纤维瘤病）的成人中的临床活性。
J Clin Oncol. 2017 May 10;35(14):1561-1569. doi: 10.1200/JCO.2016.71.1994. Epub 2017 Mar 28.
2
A Phase I, dose-finding study in patients with advanced solid malignancies of the oral γ-secretase inhibitor PF-03084014.一项评估口服 γ-分泌酶抑制剂 PF-03084014 在晚期实体瘤患者中的 I 期、剂量探索研究。
Clin Cancer Res. 2015 Jan 1;21(1):60-7. doi: 10.1158/1078-0432.CCR-14-0607. Epub 2014 Sep 17.
3
Safety profile of semagacestat, a gamma-secretase inhibitor: IDENTITY trial findings.γ-分泌酶抑制剂司马吉司他的安全性概况：IDENTITY试验结果
Curr Med Res Opin. 2014 Oct;30(10):2021-32. doi: 10.1185/03007995.2014.939167. Epub 2014 Jul 14.
4
A phase 3 trial of semagacestat for treatment of Alzheimer's disease.一项用于治疗阿尔茨海默病的司美吉林的 3 期临床试验。
N Engl J Med. 2013 Jul 25;369(4):341-50. doi: 10.1056/NEJMoa1210951.
5
γ-Secretase mutations in hidradenitis suppurativa: new insights into disease pathogenesis.γ-分泌酶突变与化脓性汗腺炎：对疾病发病机制的新认识。
J Invest Dermatol. 2013 Mar;133(3):601-607. doi: 10.1038/jid.2012.372. Epub 2012 Oct 25.
6
Comorbidities of hidradenitis suppurativa (acne inversa).化脓性汗腺炎（反向性痤疮）的合并症。
Dermatoendocrinol. 2010 Jan;2(1):9-16. doi: 10.4161/derm.2.1.12490.
7
Hidradenitis suppurativa: a disease of the absent sebaceous gland? Sebaceous gland number and volume are significantly reduced in uninvolved hair follicles from patients with hidradenitis suppurativa.化脓性汗腺炎：一种缺失皮脂腺的疾病？化脓性汗腺炎患者未受累的毛囊中皮脂腺数量和体积显著减少。
Br J Dermatol. 2011 May;164(5):1017-22. doi: 10.1111/j.1365-2133.2011.10224.x.
8
What causes hidradenitis suppurativa?化脓性汗腺炎的病因是什么？
Exp Dermatol. 2008 May;17(5):455-6; discussion 457-72. doi: 10.1111/j.1600-0625.2008.00712_1.x.
9
gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis.γ-分泌酶通过Notch信号通路发挥作用以维持皮肤附属器，但它们的模式形成或初始形态发生并不需要γ-分泌酶。
Dev Cell. 2004 Nov;7(5):731-43. doi: 10.1016/j.devcel.2004.09.014.

Hidradenitis Suppurativa-Like Lesions Associated with Pharmacologic Inhibition of Gamma-Secretase.

作者信息

O'Sullivan Coyne Geraldine, Woodring Therese S, Lee Chyi-Chia R, Chen Alice P, Kong Heidi H

机构信息

Early Clinical Trials Developmental Program, DCTD, National Cancer Institute, Bethesda, Maryland, USA.

Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

出版信息

J Invest Dermatol. 2018 Apr;138(4):979-981. doi: 10.1016/j.jid.2017.09.051. Epub 2017 Nov 11.

DOI:10.1016/j.jid.2017.09.051
PMID:29138057
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8108066/
Abstract
摘要