Pasand Zahra Sanaye, Erfanian Reza, Masbough Farnoosh, Asanjarani Behzad, Sohrabpour Saeed
Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Ann Med Surg (Lond). 2025 Jul 16;87(8):4870-4874. doi: 10.1097/MS9.0000000000003543. eCollection 2025 Aug.
Pharyngocutaneous fistula represents a significant complication following total laryngectomy. This study aims to explore the relationship between vitamin C administration and the formation of pharyngocutaneous fistulas.
This open-label randomized controlled trial involved 47 patients diagnosed with laryngeal cancer. Participants were randomly allocated to either an intervention group or a placebo group. Those in the intervention group received 1 gram of vitamin C via injection twice daily ( = 23), while the placebo group received an equivalent volume of distilled water ( = 24) during their postoperative recovery. The occurrence of pharyngocutaneous fistula was monitored in both groups after 1 month.
A total of 27.66% (13 patients) developed pharyngocutaneous fistulas. The incidence in the vitamin C group was lower at 21.74%, compared to 33.33% in the control group; however, this difference did not reach statistical significance ( = 0.374).
Although this study offers important insights into the potential impact of vitamin C on the postoperative care of laryngeal cancer patients, the results indicate that further research with larger sample sizes and varied methodologies is required to establish definitive conclusions.
咽瘘是全喉切除术后的一种严重并发症。本研究旨在探讨维生素C的使用与咽瘘形成之间的关系。
这项开放标签随机对照试验纳入了47例被诊断为喉癌的患者。参与者被随机分配到干预组或安慰剂组。干预组患者术后恢复期间每天两次静脉注射1克维生素C（n = 23），而安慰剂组接受等量的蒸馏水（n = 24）。1个月后监测两组咽瘘的发生情况。
共有27.66%（13例患者）发生咽瘘。维生素C组的发生率较低，为21.74%，而对照组为33.33%；然而，这种差异未达到统计学显著性（P = 0.374）。
尽管本研究为维生素C对喉癌患者术后护理的潜在影响提供了重要见解，但结果表明，需要采用更大样本量和不同方法进行进一步研究，以得出明确结论。
