Department of Otolaryngology, Otolaryngology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Curr Drug Saf. 2024;19(1):129-133. doi: 10.2174/1574886318666230331100122.
Nutritional factors in developing some malignancies have been investigated recently.
In this study, we evaluated the role of vitamin D in advanced laryngeal cancer and its association with the development of pharyngocutaneous fistula (PCF) following total laryngectomy.
A cross-sectional, case-control study was conducted.
Fifty-five patients with advanced laryngeal cancer referred for total laryngectomy were included. We also considered 55 healthy individuals after matching age and sex as a control group. Serum levels of 25(OH)D were measured using a commercially available enzyme-linked immunosorbent assay (ELISA) kit. The association of serum 25(OH)D with PCF following total laryngectomy was also determined.
Vitamin D was significantly lower in patients with advanced laryngeal cancer than in the control group ( < 0.001). Moreover, our results showed that a mean serum concentration of 25(OH)D in patients with PCF was significantly lower than in patients without PCF ( < 0.001).
Vitamin D deficiency is highly prevalent in advanced laryngeal cancer, most pronounced in those who develop a PFC following total laryngectomy.
最近研究了一些恶性肿瘤发生发展中的营养因素。
本研究评估了维生素 D 在晚期喉癌中的作用及其与全喉切除术后咽皮瘘（PCF）发生的关系。
这是一项横断面病例对照研究。
纳入 55 例晚期喉癌患者作为病例组，并选取年龄和性别相匹配的 55 例健康者作为对照组。采用商业酶联免疫吸附试验（ELISA）试剂盒检测血清 25（OH）D 水平。还确定了全喉切除术后血清 25（OH）D 与 PCF 的关系。
与对照组相比，晚期喉癌患者的维生素 D 水平明显降低（<0.001）。此外，我们的结果显示，发生 PCF 的患者的平均血清 25（OH）D 浓度明显低于未发生 PCF 的患者（<0.001）。
晚期喉癌患者中维生素 D 缺乏症非常普遍，在全喉切除术后发生咽皮瘘的患者中更为明显。
