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小细胞肺癌的人口统计学和种族差异:从诊断到治疗时间、寻求放化疗以及发病率的趋势——一项基于监测、流行病学和最终结果(SEER)数据库分析(2000 - 2021年)及贝叶斯多级回归建模

Demographic and racial disparities in small-cell lung carcinoma: trends in diagnosis to treatment time, chemoradiotherapy seeking, and incidence rates-A SEER database analysis (2000-2021) with Bayesian multilevel regression modeling.

作者信息

Khalil Ibrahim, Hossain Md Imran, Akter Mahmuda

机构信息

Dhaka Medical College and Hospital, Bangladesh.

Faculty of Medicine, Dhaka University, Dhaka, Bangladesh.

出版信息

Ann Med Surg (Lond). 2025 Jul 16;87(8):4785-4802. doi: 10.1097/MS9.0000000000003593. eCollection 2025 Aug.


DOI:10.1097/MS9.0000000000003593
PMID:40787574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12333719/
Abstract

BACKGROUND: Small cell-lung carcinoma (SCLC) is an aggressive cancer with poor prognosis, influenced by demographic factors such as race, sex, and age. Racial and demographic disparities in SCLC incidence and treatment outcomes are evident, with minorities experiencing higher incidence rates. Understanding these disparities is essential for addressing healthcare inequities. METHODS: This study analyzed 243 825 SCLC cases from the Surveillance, Epidemiology, and End Results database (2000-2021), examining demographic variables (age, sex, race) and their effects on treatment-seeking behavior and treatment delays using Bayesian multilevel regression modeling. RESULTS: The cohort consisted of 48.2% males and 51.8% females, with a racial composition of 35.1% White, 25.5% Black, 22.5% Asian/Pacific Islander, and 16.9% American Indian/Alaska Native. American Indian/Alaska Native individuals had a higher incidence of SCLC (β = 6.47, 95% CI: 5.26-7.69, < 0.0001), followed by White (β = 4.85, 95% CI: 3.86-5.84, < 0.0001) and Black (β = 4.15, 95% CI: 3.12-5.17, < 0.0001) patients compared to Asian/Pacific Islander patients. No significant racial disparities were observed in chemotherapy (χ = 0.84, df = 6, = 0.9909), radiotherapy (χ = 14.75, df = 27, = 0.9728), or time to treatment initiation (χ = 12.36, df = 9, = 0.1938). Bayesian regression models confirmed higher SCLC incidence in older age groups (70-74 years: β = 9.62, 95% CrI: [1.77, 17.71]; 75-79 years: β = 12.87, 95% CrI: [5.06, 20.99]; 80-84 years: β = 12.80, 95% CrI: [5.03, 20.89]; 85 + years: β = 8.16, 95% CrI: [0.38, 16.24]) and males (β = 3.77, 95% CrI: [3.37, 4.17], R = 1.00) compared to females. CONCLUSION: This study highlights significant racial and demographic disparities in SCLC incidence, particularly among minority populations. While treatment-seeking behaviors and delays did not exhibit significant racial differences, age and sex were critical factors influencing SCLC incidence.

摘要

背景:小细胞肺癌(SCLC)是一种侵袭性癌症,预后较差,受种族、性别和年龄等人口统计学因素影响。SCLC发病率和治疗结果方面的种族和人口统计学差异明显,少数族裔的发病率较高。了解这些差异对于解决医疗保健不平等问题至关重要。 方法:本研究分析了监测、流行病学和最终结果数据库(2000 - 2021年)中的243825例SCLC病例,使用贝叶斯多级回归模型研究人口统计学变量(年龄、性别、种族)及其对寻求治疗行为和治疗延迟的影响。 结果:该队列中男性占48.2%,女性占51.8%,种族构成分别为白人35.1%、黑人25.5%、亚太岛民22.5%、美洲印第安人/阿拉斯加原住民16.9%。美洲印第安人/阿拉斯加原住民的SCLC发病率较高(β = 6.47,95%置信区间:5.26 - 7.69,P < 0.0001),其次是白人(β =

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本文引用的文献

[1]
Survival prognostic nomogram for young metastatic non-small cell lung cancer: a study of the US SEER database and a Chinese cohort.

Front Oncol. 2025-2-14

[2]
Cancer incidence and mortality estimates in 2022 in southeast Asia: a comparative analysis.

Lancet Oncol. 2025-4

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Metastatic sites, prognosis, and a new nomogram for predicting overall survival among small cell lung cancer patients with liver metastasis: a retrospective study based on SEER.

J Thorac Dis. 2025-1-24

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Structural Racism as a Contributor to Lung Cancer Incidence and Mortality Rates Among Black Populations in the United States.

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Impact of U.S. Preventive Services Task Force lung cancer screening update on drivers of disparities in screening eligibility.

Cancer Med. 2023-2

[10]
STROCSS 2021: Strengthening the reporting of cohort, cross-sectional and case-control studies in surgery.

Int J Surg. 2021-12

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