Liu Jianqiang, Li Xiaoyan, Hou Shenggui, Dou Aixia
Department of Joint Surgery, The Fourth People's Hospital, Jinan, China.
Department of Haematology, The Second Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China.
Ann Med Surg (Lond). 2025 Jul 22;87(8):4848-4852. doi: 10.1097/MS9.0000000000003572. eCollection 2025 Aug.
To study the effect of Sheng Xuexiaoban capsules (SXXCs) on restoring immune dysfunction in ITP model mice.
We assessed changes in platelet counts, megakaryocyte counts, Treg functions, interleukin-2 expression, and other indicators to investigate the effect of SXXCs in the ITP mouse model.
After treatment of the ITP mouse model with SXXCs, we found increases in platelets (577.35 ± 76.94 vs. 123.33 ± 16.24, < 0.05) and the Treg number (7.35 ± 1.94 vs. 1.33 ± 1.24), and Foxp3 mRNA expression (2: 0.2493 ± 0.03102 vs. 0.683 ± 0.05774, = 0.0027). Decreased interleukin-2 produced by effector T cells was detected (2: 0.6119 ± 0.01173 vs. 2.838 ± 0.1004, < 0.001). SXXCs treatment significantly improved the proportion and function of Tregs. By increasing Foxp3 mRNA expression and decreasing interleukin-2, we restored immune tolerance to achieve a good therapeutic effect in ITP model mice.
We confirmed that SXXCs have a good therapeutic effect on ITP. Simultaneously we verified the important role of Tregs in ITP pathogenesis.
研究升血消斑胶囊（SXXCs）对免疫性血小板减少性紫癜（ITP）模型小鼠免疫功能紊乱的恢复作用。
通过评估血小板计数、巨核细胞计数、调节性T细胞（Treg）功能、白细胞介素-2表达等指标，研究SXXCs对ITP小鼠模型的影响。
用SXXCs治疗ITP小鼠模型后，发现血小板数量（577.35 ± 76.94对123.33 ± 16.24，P < 0.05）、Treg数量（7.35 ± 1.94对1.33 ± 1.24）及叉头框蛋白3（Foxp3）mRNA表达（2：0.2493 ± 0.03102对0.683 ± 0.05774，P = = 0.0027）均增加。检测到效应T细胞产生的白细胞介素-2减少（2：0.6119 ± 0.01173对2.838 ± 0. 1004，P < 0.001）。SXXCs治疗显著改善了Tregs的比例和功能。通过增加Foxp3 mRNA表达并减少白细胞介素-2，恢复了免疫耐受，从而在ITP模型小鼠中取得了良好的治疗效果。
证实SXXCs对ITP有良好的治疗作用。同时验证了Tregs在ITP发病机制中的重要作用。
