Ghadially F N, Mierau G W
J Submicrosc Cytol. 1985 Oct;17(4):645-50.
In a largely haemorrhagic and necrotic specimen of Ewing's sarcoma we found banded structures (periodicity of banding about 250 nm) of a type hitherto not known to occur in any normal or pathological tissue. Morphological appearances suggested that these structures had evolved from the fibrin which was always closely associated with them. However, this idea was abandoned because the periodicity of banding of these structures is about ten times greater than the known periodicity of banding of fibrin. These structures have the same periodicity of banding as fibrous long-spacing collagen produced in vitro and about twice the periodicity of banding of fibrous long-spacing collagen found in vivo. However, they lack the fine striations or minor bands of the in vitro fibrous long-spacing collagen. We therefore conclude that the banded structures in this tumour represent a new form of fibrous long-spacing collagen which shares the features of in vitro and in vivo types of fibrous long-spacing collagen.
在一个尤因肉瘤的大体上呈出血性和坏死性的标本中，我们发现了一种带状结构（带纹周期约为250纳米），这种结构迄今在任何正常或病理组织中均未见过。形态学表现提示这些结构是由始终与其紧密相关的纤维蛋白演变而来。然而，这一想法被摒弃了，因为这些结构的带纹周期比已知的纤维蛋白带纹周期大约十倍。这些结构的带纹周期与体外产生的纤维状长间距胶原相同，约为体内发现的纤维状长间距胶原带纹周期的两倍。然而，它们缺乏体外纤维状长间距胶原的精细条纹或小带。因此，我们得出结论，该肿瘤中的带状结构代表了一种新型的纤维状长间距胶原，它兼具体外和体内纤维状长间距胶原的特征。
