Adlimoghaddam Aida
Department of Neurology, Dale and Deborah Smith Center for Alzheimer's Research and Treatment, Neuroscience Institute, Southern Illinois University School of Medicine, Springfield, Illinois, USA.
Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, USA.
Aging Dis. 2025 Jul 31;16(5):2495-2497. doi: 10.14336/AD.2025.10731.
Mitochondrial dysfunction is increasingly recognized as a unifying mechanism underlying aging and a wide range of age-related diseases. This special issue brings together recent advances that elucidate how impaired mitochondrial function contributes to neurodegenerative, cardiovascular, and metabolic disorders. The featured articles highlight molecular pathways of mitochondrial decline, its systemic consequences, and potential interventions aimed at restoring mitochondrial health. Collectively, these studies reinforce the concept that targeting mitochondrial integrity holds significant promise for promoting healthy aging and preventing chronic disease.
线粒体功能障碍日益被认为是衰老以及一系列与年龄相关疾病背后的统一机制。本期特刊汇集了近期的进展，阐明了线粒体功能受损如何导致神经退行性疾病、心血管疾病和代谢紊乱。专题文章重点介绍了线粒体衰退的分子途径、其系统性后果以及旨在恢复线粒体健康的潜在干预措施。总体而言，这些研究强化了这样一个概念，即针对线粒体完整性对于促进健康衰老和预防慢性病具有重大前景。
