[一种新开发的γ-球蛋白制剂（SM-4300）与某些抗生素对严重细菌感染的协同作用]
[The concomitant effect of a newly developed gamma-globulin preparation (SM-4300) with some antibiotics on severe bacterial infections].
作者信息
Shigeno Y, Koga H, Nagasawa M, Tanaka H, Fukuda Y, Tomonaga A, Suzuyama Y, Yamaguchi K, Izumikawa K, Saito A
出版信息
Jpn J Antibiot. 1985 Sep;38(9):2547-57.
Twenty-six patients with bacterial infections, mainly respiratory infections, were treated with newly developed gamma-globulin preparation (SM-4300), as a combination therapy with some antibiotics. The result was as follows. Clinical effects of 18 cases evaluated were excellent in 1 case (5.6%), good in 10 (55.6%), fair in 4 (22.2%) and poor in 3 (16.7%). No remarkable adverse reactions and abnormal value in laboratory data due to administration of SM-4300 were observed. Significant changes of complement system before and after administration of SM-4300 were not observed. It was considered that SM-4300 was effective as a combination therapy with some antibiotics for the treatment of severe or refractory bacterial infections.
26例主要为呼吸道感染的细菌感染患者接受了新研发的γ-球蛋白制剂（SM-4300）治疗，并与某些抗生素联合使用。结果如下。在评估的18例患者中，临床疗效为优的有1例（5.6%），良的有10例（55.6%），中（尚可）的有4例（22.2%），差的有3例（16.7%）。未观察到因使用SM-4300而出现的明显不良反应及实验室数据异常值。未观察到使用SM-4300前后补体系统的显著变化。认为SM-4300作为与某些抗生素联合治疗严重或难治性细菌感染是有效的。
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