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Sex-dependent epigenetic disruption of YY1 binding by prenatal BPA exposure downregulates Matr3 and alters Agap1 splicing in the offspring hippocampus.

作者信息

Lertpeerapan Pattanachat, Kanlayaprasit Songphon, Thongkorn Surangrat, Kasitipradit Kasidit, Panjabud Pawinee, Songsritaya Kwanjira, Jantheang Thanawin, Morita Masanobu, Akaike Takaaki, Hu Valerie W, Jindatip Depicha, Saeliw Thanit, Sarachana Tewarit

机构信息

The Ph.D. program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.

Chulalongkorn Autism Research and Innovation Center of Excellence (ChulaACE), Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.

出版信息

Biol Sex Differ. 2025 Aug 11;16(1):63. doi: 10.1186/s13293-025-00744-1.

DOI:10.1186/s13293-025-00744-1
PMID:40790242
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12337383/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbb9/12337383/b95f4d9ef927/13293_2025_744_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbb9/12337383/cb4c555acd74/13293_2025_744_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbb9/12337383/333d05a35c0d/13293_2025_744_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbb9/12337383/b79a03a9555a/13293_2025_744_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbb9/12337383/1aaf32083c21/13293_2025_744_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbb9/12337383/bede1ace3264/13293_2025_744_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbb9/12337383/d6d682004ddc/13293_2025_744_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbb9/12337383/b166a4ceb7f4/13293_2025_744_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbb9/12337383/59abdfce9196/13293_2025_744_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbb9/12337383/b95f4d9ef927/13293_2025_744_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbb9/12337383/cb4c555acd74/13293_2025_744_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbb9/12337383/333d05a35c0d/13293_2025_744_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbb9/12337383/b79a03a9555a/13293_2025_744_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbb9/12337383/1aaf32083c21/13293_2025_744_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbb9/12337383/bede1ace3264/13293_2025_744_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbb9/12337383/d6d682004ddc/13293_2025_744_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbb9/12337383/b166a4ceb7f4/13293_2025_744_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbb9/12337383/59abdfce9196/13293_2025_744_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbb9/12337383/b95f4d9ef927/13293_2025_744_Fig9_HTML.jpg

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iScience. 2025 Jul 5;28(8):113062. doi: 10.1016/j.isci.2025.113062. eCollection 2025 Aug 15.
2
Prenatal exposure to bisphenol A disrupts RNA splicing in the prefrontal cortex and promotes behaviors related to autism in offspring.产前暴露于双酚A会破坏前额叶皮质中的RNA剪接，并促进后代与自闭症相关的行为。
Sci Rep. 2025 Jul 17;15(1):25996. doi: 10.1038/s41598-025-09909-9.
3
Prevalence and Early Identification of Autism Spectrum Disorder Among Children Aged 4 and 8 Years - Autism and Developmental Disabilities Monitoring Network, 16 Sites, United States, 2022.
4至8岁儿童自闭症谱系障碍的患病率及早期识别——自闭症与发育障碍监测网络，美国16个地点，2022年
MMWR Surveill Summ. 2025 Apr 17;74(2):1-22. doi: 10.15585/mmwr.ss7402a1.
4
Bisphenol A exposure and neurodevelopmental disorders and problems in children under 12 years of age: A systematic review and meta-analysis.双酚A暴露与12岁以下儿童的神经发育障碍及问题：一项系统综述与荟萃分析
J Hazard Mater. 2025 Jun 15;490:137731. doi: 10.1016/j.jhazmat.2025.137731. Epub 2025 Mar 1.
5
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