Tsuchisaka H, Takase M
Jpn J Ophthalmol. 1985;29(3):263-71.
In adult albino rabbits, an opening wound was made in the central area of the cornea in one eye and the anterior chamber was made flat for 48 hours. Fluorescein-labeled dextran with a molecular weight of 70,000 was injected intravenously, and the uveal tissues were examined by fluorescence microscopy. A marked leakage of fluorescein-dextran was seen to occur from the vessels of the iris, ciliary body, anterior choroid and also even in the posterior choroid. The degree of leakage was similar during the period from 30 minutes to 48 hours after the surgery. In the fellow normal eyes, the leakage was minimal. In some eyes, the aqueous humor was aspirated and subsequently the anterior chamber was reformed spontaneously; the leakage of fluorescein-dextran determined 6 hours later was much less than after the filtering surgery. Some eyes were pretreated by topical 0.3% flurbiprofen solution or 0.3% indomethacin oil drop before the filtering surgery was performed. The pretreatment significantly reduced leakage of fluorescein-dextran from the uveal vessels, but the pretreatment with topical 0.1% betamethasone had only a slight effect.
在成年白化兔中，对一只眼睛的角膜中央区域造成开放性伤口，并使前房变平48小时。静脉注射分子量为70,000的荧光素标记右旋糖酐，然后通过荧光显微镜检查葡萄膜组织。可见虹膜、睫状体、脉络膜前部甚至脉络膜后部的血管有明显的荧光素-右旋糖酐渗漏。术后30分钟至48小时期间渗漏程度相似。在对侧正常眼中，渗漏极少。在一些眼睛中，抽取房水，随后前房自发恢复；6小时后测定的荧光素-右旋糖酐渗漏比滤过手术后少得多。在进行滤过手术前，一些眼睛用局部0.3%氟比洛芬溶液或0.3%吲哚美辛油滴眼进行预处理。预处理显著减少了葡萄膜血管中荧光素-右旋糖酐的渗漏，但局部用0.1%倍他米松预处理只有轻微效果。
