Tamai K, Majima A, Yan C
Department of Ophthalmology, Nagoya City University Medical School, Japan.
Jpn J Ophthalmol. 1995;39(1):43-8.
Effects of local hypothermia on uveal blood flow and postoperative inflammation were evaluated in experimental vitrectomy in albino rabbits. Solutions used for intraocular perfusion were maintained at 9 degrees C, 22 degrees C or 37 degrees C. Following closed vitrectomy, the vitreous cavity was irrigated for 60 minutes. Temperatures at various sites and uveal blood flow were measured before and during the procedure. Aqueous protein concentrations were checked on postoperative days 1, 7 and 14. There was a larger decrease in temperature at the retina than at the choroid or the ciliary body. Blood flow at the ciliary body was reduced to 76.0% and that at the choroid to 77.0% of the preoperative level after 60 minutes of irrigation at 9 degrees C. The decrease was 91.0% and 88.3%, respectively, after 60 minutes of irrigation at 22 degrees C. Aqueous protein concentrations in the 9 degrees C and 22 degrees C groups were significantly lower than those in the 37 degrees C group on the first postoperative day in the eyes irrigated for 60 minutes. In the eyes irrigated for 30 minutes, however, no significant differences were seen. Local hypothermia during prolonged vitrectomy seems to decrease inflammation in the early postoperative stage.
在白化兔实验性玻璃体切除术中评估了局部低温对葡萄膜血流和术后炎症的影响。用于眼内灌注的溶液保持在9摄氏度、22摄氏度或37摄氏度。闭合式玻璃体切除术后，玻璃体腔冲洗60分钟。在手术前和手术过程中测量了不同部位的温度和葡萄膜血流。在术后第1天、第7天和第14天检查房水蛋白浓度。视网膜的温度下降幅度大于脉络膜或睫状体。在9摄氏度下冲洗60分钟后，睫状体的血流减少到术前水平的76.0%，脉络膜的血流减少到术前水平的77.0%。在22摄氏度下冲洗60分钟后，减少幅度分别为91.0%和88.3%。在冲洗60分钟的眼中，9摄氏度和22摄氏度组术后第一天的房水蛋白浓度显著低于37摄氏度组。然而，在冲洗30分钟的眼中，未观察到显著差异。长时间玻璃体切除术中的局部低温似乎会降低术后早期的炎症反应。
