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肠道微生物群与非特应性喘息的轨迹：学龄前哮喘的早期微生物印记。

Trajectories of gut microbiota and nonatopic wheeze: an early-life microbial footprint on preschool asthma.

作者信息

Miyachi Hideaki, Makrinioti Heidi

机构信息

Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Division of Pulmonary Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

出版信息

ERJ Open Res. 2025 Aug 11;11(4). doi: 10.1183/23120541.00437-2025. eCollection 2025 Jul.

DOI:10.1183/23120541.00437-2025
PMID:40791920
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12336993/
Abstract

https://bit.ly/4jNAPgI.

摘要

https://bit.ly/4jNAPgI. （此为网址，无法准确翻译为中文，保留原文即可）

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc77/12336993/3263c580bcca/00437-2025.01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc77/12336993/3263c580bcca/00437-2025.01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc77/12336993/3263c580bcca/00437-2025.01.jpg

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本文引用的文献

1
The role of the early-life gut microbiome in childhood asthma.早期肠道微生物群在儿童哮喘中的作用。
Gut Microbes. 2025 Dec;17(1):2457489. doi: 10.1080/19490976.2025.2457489. Epub 2025 Jan 30.
2
Integrated nasopharyngeal airway metagenome and asthma genetic risk endotyping of severe bronchiolitis in infancy and risk of childhood asthma.婴儿期重症细支气管炎的鼻咽气道宏基因组与哮喘遗传风险分型及儿童哮喘风险
Eur Respir J. 2024 Sep 26;64(6). doi: 10.1183/13993003.01130-2024. Print 2024 Dec.
3
Link between gut microbiota dysbiosis and childhood asthma: Insights from a systematic review.
肠道微生物群失调与儿童哮喘之间的联系：一项系统评价的见解
J Allergy Clin Immunol Glob. 2024 Jun 12;3(3):100289. doi: 10.1016/j.jacig.2024.100289. eCollection 2024 Aug.
4
Environmental influences on childhood asthma-The effect of diet and microbiome on asthma.环境对儿童哮喘的影响——饮食和微生物组对哮喘的影响。
Pediatr Allergy Immunol. 2022 Dec;33(12):e13892. doi: 10.1111/pai.13892.
5
Microbial dysbiosis and childhood asthma development: Integrated role of the airway and gut microbiome, environmental exposures, and host metabolic and immune response.微生物失调与儿童哮喘发病机制：气道和肠道微生物组、环境暴露以及宿主代谢和免疫反应的综合作用
Front Immunol. 2022 Sep 30;13:1028209. doi: 10.3389/fimmu.2022.1028209. eCollection 2022.
6
Exclusive breast-feeding, the early-life microbiome and immune response, and common childhood respiratory illnesses.纯母乳喂养、生命早期微生物组与免疫应答和常见儿童呼吸道疾病。
J Allergy Clin Immunol. 2022 Sep;150(3):612-621. doi: 10.1016/j.jaci.2022.02.023. Epub 2022 Mar 10.
7
Multiplexed functional metagenomic analysis of the infant microbiome identifies effectors of NF-κB, autophagy, and cellular redox state.婴儿微生物组的多功能宏基因组学分析鉴定了 NF-κB、自噬和细胞氧化还原状态的效应因子。
Cell Rep. 2021 Sep 21;36(12):109746. doi: 10.1016/j.celrep.2021.109746.
8
Gut microbial dysbiosis is associated with allergen-specific IgE responses in young children with airway allergies.肠道微生物失调与患有气道过敏的幼儿的过敏原特异性IgE反应有关。
World Allergy Organ J. 2019 Mar 25;12(3):100021. doi: 10.1016/j.waojou.2019.100021. eCollection 2019.
9
Association of nasopharyngeal microbiota profiles with bronchiolitis severity in infants hospitalised for bronchiolitis.因毛细支气管炎住院的婴儿鼻咽微生物群特征与毛细支气管炎严重程度的关联。
Eur Respir J. 2016 Nov;48(5):1329-1339. doi: 10.1183/13993003.00152-2016. Epub 2016 Oct 6.
10
The microbial environment and its influence on asthma prevention in early life.微生物环境及其对生命早期预防哮喘的影响。
J Allergy Clin Immunol. 2016 Mar;137(3):680-9. doi: 10.1016/j.jaci.2015.12.1301. Epub 2016 Jan 22.