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协同更优：用于高性能肿瘤治疗的仿生纳米药物

Better together: biomimetic nanomedicines for high performance tumor therapy.

作者信息

Mohammad Imran Shair, Kursunluoglu Gizem, Patel Anup Kumar, Ishaq Hafiz Muhammad, Tunc Cansu Umran, Kanarya Dilek, Rehman Mubashar, Aydin Omer, Lifang Yin

机构信息

Department of Radiology, City of Hope National Medical Center, 1500 East Duarte Rd., Duarte, California 91010, USA.

Nanothera Lab, Drug Application and Research Center (ERFARMA), Erciyes University, 38039, Kayseri, Turkey.

出版信息

Beilstein J Nanotechnol. 2025 Aug 5;16:1246-1276. doi: 10.3762/bjnano.16.92. eCollection 2025.

DOI:10.3762/bjnano.16.92
PMID:40791939
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12337993/
Abstract

The emergence of nanotechnology offers a promising avenue for enhancing cancer treatment outcomes. In this context, biomimetic nanoparticles have emerged as an exciting frontier in the field of biomedicine. These nanoparticles can emulate essential biological functions, drawing from an abundant reservoir of cellular capabilities. This includes engaging in biological binding, precise homing to tumor sites, and interaction with immune cells. These inherent traits endow biomimetic nanoparticles with a suite of intelligent features, including biocompatibility, low immunogenicity, reduced toxicity, immune evasion, prolonged circulation, homotypic binding, enhanced tumor targeting, and the capability of precise delivery. By integrating biologically inspired coatings derived from cell membranes with nanoparticle cores, these carriers become highly versatile vessels for encapsulating a wide array of therapeutic agents. As a result, they are being extensively harnessed for the precise delivery of drugs and genes, underpinning numerous biomedical applications. This discussion delves into the challenges and opportunities presented by biomimetic nanoparticles and offers a comprehensive exploration of their fundamentals and recent breakthroughs, with an eye towards clinical translation. By bridging the gap between scientific innovation and clinical utility, biomimetic nanoparticles hold great promise for advancing the field of cancer treatment.

摘要

纳米技术的出现为提高癌症治疗效果提供了一条充满希望的途径。在此背景下，仿生纳米颗粒已成为生物医学领域一个令人兴奋的前沿领域。这些纳米颗粒可以模拟基本的生物学功能，借鉴丰富的细胞功能储备。这包括进行生物结合、精确归巢到肿瘤部位以及与免疫细胞相互作用。这些固有特性赋予仿生纳米颗粒一系列智能特性，包括生物相容性、低免疫原性、降低毒性、免疫逃逸、延长循环时间、同型结合、增强肿瘤靶向性以及精确递送能力。通过将源自细胞膜的仿生涂层与纳米颗粒核心相结合，这些载体成为用于封装多种治疗剂的高度通用的容器。因此，它们正被广泛用于药物和基因的精确递送，支撑着众多生物医学应用。本讨论深入探讨了仿生纳米颗粒带来的挑战和机遇，并对其基本原理和近期突破进行了全面探索，着眼于临床转化。通过弥合科学创新与临床应用之间的差距，仿生纳米颗粒在推进癌症治疗领域方面具有巨大潜力。

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