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男性学中的水凝胶技术：研究进展与潜在应用

Hydrogel technologies in andrology: advances in research and prospective applications.

作者信息

Guo Xinlei, Zhang Jingyi, Guan Yanxin, Tian Xingzhao, Gong Yanan, Xiao Yao, Yang Fang, Chang Degui, Yu Xujun

机构信息

TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

出版信息

Front Pharmacol. 2025 Jul 28;16:1635007. doi: 10.3389/fphar.2025.1635007. eCollection 2025.

DOI:10.3389/fphar.2025.1635007
PMID:40792211
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12336496/
Abstract

Hydrogels, owing to their outstanding physicochemical properties and excellent biocompatibility, have emerged as a focal point of research and clinical application in andrological diseases. This review systematically summarizes cutting-edge progress in hydrogel applications for Prostate Cancer (PC), Bladder Cancer (BC), Erectile Dysfunction (ED), Male Reproductive Medicine (MRM), and urinary tract tissue engineering. Current studies indicate that hydrogels can serve as protective spacers in PC radiotherapy to mitigate radiation-induced rectal toxicity and as precise drug-delivery vehicles to enhance antitumor efficacy. Moreover, hydrogels demonstrate unique and broad potential in neurovascular repair, immunomodulation, sperm selection, spermatogenesis modeling, and tissue regeneration. Future advancements in hydrogel technology-through intelligent responsive design, integration of bioactive molecules, incorporation of advanced manufacturing processes, and rigorous translational research-are expected to significantly elevate treatment standards for andrological diseases and improve patient quality of life.

摘要

水凝胶因其出色的物理化学性质和卓越的生物相容性，已成为男科疾病研究和临床应用的焦点。本综述系统总结了水凝胶在前列腺癌（PC）、膀胱癌（BC）、勃起功能障碍（ED）、男性生殖医学（MRM）和尿路组织工程中的前沿应用进展。当前研究表明，水凝胶可在PC放疗中作为保护间隔物，减轻辐射引起的直肠毒性，并作为精确的药物递送载体，提高抗肿瘤疗效。此外，水凝胶在神经血管修复、免疫调节、精子筛选、精子发生建模和组织再生方面展现出独特且广阔的潜力。水凝胶技术未来的进展——通过智能响应设计、生物活性分子整合、先进制造工艺的引入以及严格的转化研究——有望显著提高男科疾病的治疗标准，改善患者生活质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cc3/12336496/6a3493ce7a5d/fphar-16-1635007-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cc3/12336496/97784aaac0ce/FPHAR_fphar-2025-1635007_wc_abs.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cc3/12336496/ad1e7ede02f5/fphar-16-1635007-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cc3/12336496/97784aaac0ce/FPHAR_fphar-2025-1635007_wc_abs.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cc3/12336496/095b7f6b5176/fphar-16-1635007-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cc3/12336496/6b779c864901/fphar-16-1635007-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cc3/12336496/5211d9dbd215/fphar-16-1635007-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cc3/12336496/a707660ba34d/fphar-16-1635007-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cc3/12336496/ad1e7ede02f5/fphar-16-1635007-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cc3/12336496/284cc818c7af/fphar-16-1635007-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cc3/12336496/6a3493ce7a5d/fphar-16-1635007-g009.jpg

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