Fukunaga Naoki, Terai Hideki, Nomura Rui, Kurebayashi Yutaka, Nakamura Kohei, Kawano Ryutaro, Shigeta Kohei, Okabayashi Koji, Kinoshita Katsuhito, Ogata Akihiko, Shigematsu Lisa, Ito Fumimaro, Takaoka Hatsuyo, Fukushima Takahiro, Nukaga Shigenari, Ohgino Keiko, Yasuda Hiroyuki, Nishihara Hiroshi, Kitagawa Yuko, Fukunaga Koichi
Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Keio Cancer Center, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
JTO Clin Res Rep. 2025 Jun 13;6(9):100862. doi: 10.1016/j.jtocrr.2025.100862. eCollection 2025 Sep.
Histologic transformation from adenocarcinoma to SCLC is a recognized mechanism of resistance in lung cancer. However, the transformation into squamous cell carcinoma is less common, and the associated genomic alterations remain unclear. Here, we present a case of lung adenocarcinoma harboring an EGFR () mutation that transformed into squamous cell carcinoma. Although L858R mutation was detected throughout the transformation, genomic analyses were performed during the disease course, revealing the amplification of and , which have recently been proposed as potential driver oncogenes in lung squamous cell carcinoma. This case report highlights the genomic alterations observed in repeatedly biopsied specimens, along with a review of the relevant literature.
腺癌向小细胞肺癌的组织学转化是肺癌公认的耐药机制。然而，向鳞状细胞癌的转化较为少见，相关的基因组改变仍不清楚。在此，我们报告一例携带表皮生长因子受体（EGFR）（）突变的肺腺癌转化为鳞状细胞癌的病例。尽管在整个转化过程中均检测到L858R突变，但在病程中进行了基因组分析，发现和基因扩增，这两个基因最近被认为是肺鳞状细胞癌潜在的驱动癌基因。本病例报告强调了在重复活检标本中观察到的基因组改变，并对相关文献进行了综述。
