Bisiani Joseph, Lynch Brian
Department of Orthopedics, Renaissance School of Medicine, Stony Brook University, Stony Brook, USA.
Cureus. 2025 Jul 12;17(7):e87791. doi: 10.7759/cureus.87791. eCollection 2025 Jul.
Currently, there are numerous anti-cancer drugs to prevent the spread of different neoplasms. Patients who depend on these medications as a form of treatment look to hopefully minimize the spread of cancer. However, there are well-known side effects of platinum-based chemotherapies, such as different electrolyte imbalances. These disturbances could possibly lead to the pathogenesis of tendinosis among cancer patients who take long-term platinum-based chemotherapy treatments, something that has not been thoroughly studied and warrants further investigation. Electrolyte disturbances in tendons can lead to dehydration, which can impair collagen synthesis and ultimately lead to tendon degeneration among cancer patients who are utilizing these long-term platinum cancer drugs.
目前，有许多抗癌药物可用于预防不同肿瘤的扩散。依赖这些药物进行治疗的患者希望尽可能减少癌症的扩散。然而，铂类化疗存在一些众所周知的副作用，比如不同类型的电解质失衡。这些紊乱可能会导致长期接受铂类化疗的癌症患者发生肌腱病，而这一点尚未得到充分研究，值得进一步调查。肌腱中的电解质紊乱会导致脱水，这会损害胶原蛋白的合成，并最终导致正在使用这些长期抗癌铂类药物的癌症患者出现肌腱退化。
