Regulation of viral hepatitis by N6-methyladenosine RNA methylation.

Recent studies have shown that the presence of an RNA modification, N6-methyladenosine (mA), in viral RNAs during infection significantly impacts the outcome of viral replication and pathogenesis. In particular, various functions of mA have been elucidated in hepatitis B virus (HBV), hepatitis C virus (HCV), and hepatitis delta virus (HDV). During viral infection, mA methylation not only directly affects the replication of these viruses but also regulates diverse cellular RNAs to control pathogenesis. This review aims to explore the functions of mA modification in the infectious processes and pathogenesis of HBV, HCV, and HDV. Understanding the role of mA methylation in these viral life cycles is essential for elucidating their pathogenesis and developing novel therapeutic strategies for HBV, HCV, and HDV infections.