Yang Jie, Yang Fanlei, Xu Wenhao, Yu Xiuqin, Zheng Zhaozhu, Wang Xiaoqin, Chen Kaili, Yu Jia, Li Gang
National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China.
Orthopedic Institute, Department of Orthopaedic Surgery, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou 215006, China.
Biomacromolecules. 2025 Sep 8;26(9):5715-5726. doi: 10.1021/acs.biomac.5c00505. Epub 2025 Aug 12.
Wound care is a critical concern due to the rising prevalence of chronic and infected wounds, which demands improved treatment solutions. Conventional dressings often fall short in delivering effective drug release and mechanical performance, limiting their clinical utility. In this study, we present a composite hydrogel dressing incorporating berberine-loaded silk fibroin microspheres and fibers (CGFs). This innovative dressing achieves sustained drug release and enhanced mechanical strength. The hydrogel exhibits excellent antibacterial activity (97.40 ± 0.53%) against , efficient drug loading, and prolonged release profiles. The addition of CGFs significantly enhances mechanical performance (maximum compressive strength of 295.74 ± 27.45 kPa), hemostatic efficiency (0.33%), and adaptability to dynamic wound environments. Our composite hydrogel dressing demonstrates superior biocompatibility and accelerates wound healing by promoting neovascularization, hair follicle regeneration, and collagen deposition. This multifunctional solution offers a promising advancement in next-generation wound care technologies.
由于慢性和感染性伤口的患病率不断上升，伤口护理成为一个关键问题，这需要改进治疗方案。传统敷料在实现有效的药物释放和机械性能方面往往存在不足，限制了它们的临床应用。在本研究中，我们展示了一种复合水凝胶敷料，其包含负载黄连素的丝素蛋白微球和纤维（CGFs）。这种创新敷料实现了药物的持续释放并增强了机械强度。该水凝胶对……表现出优异的抗菌活性（97.40±0.53%）、高效的药物负载和延长的释放曲线。添加CGFs显著增强了机械性能（最大抗压强度为295.74±27.45 kPa）、止血效率（0.33%）以及对动态伤口环境的适应性。我们的复合水凝胶敷料表现出卓越的生物相容性，并通过促进新血管形成、毛囊再生和胶原蛋白沉积来加速伤口愈合。这种多功能解决方案为下一代伤口护理技术带来了有前景的进展。
