Zubair Adeel S, Littig Lauren, DiCapua Daniel B, de Havenon Adam
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut.
PLoS One. 2025 Aug 12;20(8):e0329631. doi: 10.1371/journal.pone.0329631. eCollection 2025.
Stroke is a leading cause of morbidity in the United States, which prompts an exploration into its associated risk factors. Muscle disorders have been linked to an increased risk of stroke; however, research on stroke prevalence and clinical outcomes in this population is limited by small sample sizes. Although the diagnostic and treatment protocols for acute ischemic stroke are largely identical in patients with and without muscle disorders, it remains unclear whether clinical outcomes differ. This study aimed to address this gap using a large, nationally representative dataset.
We conducted a retrospective analysis of the 2016-2022 National Inpatient Sample to compare clinical outcomes in patients with and without muscle disorders hospitalized for an acute ischemic stroke.
Patients with pre-existing muscle disorders had significantly higher rates of intubation, PEG tube placement, and in-hospital mortality, as well as a lower likelihood of discharge to home, compared to those without muscle disorders.
These findings suggest that patients with muscle disorders experience worse outcomes following an ischemic stroke. Further research is needed to identify the underlying factors driving these disparities and to inform targeted strategies for improving outcomes in this vulnerable population.
中风是美国发病的主要原因，这促使人们对其相关风险因素进行探索。肌肉疾病与中风风险增加有关；然而，该人群中中风患病率和临床结局的研究因样本量小而受到限制。尽管急性缺血性中风的诊断和治疗方案在有和没有肌肉疾病的患者中基本相同，但临床结局是否不同仍不清楚。本研究旨在使用一个具有全国代表性的大型数据集来填补这一空白。
我们对2016 - 2022年全国住院患者样本进行了回顾性分析，以比较因急性缺血性中风住院的有和没有肌肉疾病的患者的临床结局。
与没有肌肉疾病的患者相比，已有肌肉疾病的患者插管、放置PEG管和院内死亡率显著更高，出院回家的可能性也更低。
这些发现表明，肌肉疾病患者缺血性中风后的结局更差。需要进一步研究以确定导致这些差异的潜在因素，并为改善这一弱势群体的结局提供有针对性的策略。
