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Cracking the Code of a Preclinical Rodent Model of HFpEF: The Mitochondrial Link.

作者信息

Ha Chae-Myeong, Wende Adam R

机构信息

Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.

出版信息

JACC Basic Transl Sci. 2025 Aug 11;10(9):101357. doi: 10.1016/j.jacbts.2025.101357.

Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc6c/12358656/167f9d245e3d/ga1.jpg

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本文引用的文献

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Integrated Systems Biology Identifies Disruptions in Mitochondrial Function and Metabolism as Key Contributors to HFpEF.
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3
Myocardial Metabolomics of Human Heart Failure With Preserved Ejection Fraction.
Circulation. 2023 Apr 11;147(15):1147-1161. doi: 10.1161/CIRCULATIONAHA.122.061846. Epub 2023 Mar 1.
5
Global burden of heart failure: a comprehensive and updated review of epidemiology.
Cardiovasc Res. 2023 Jan 18;118(17):3272-3287. doi: 10.1093/cvr/cvac013.
6
Myocardial Gene Expression Signatures in Human Heart Failure With Preserved Ejection Fraction.
Circulation. 2021 Jan 12;143(2):120-134. doi: 10.1161/CIRCULATIONAHA.120.050498. Epub 2020 Oct 29.
7
ZSF1 rat as animal model for HFpEF: Development of reduced diastolic function and skeletal muscle dysfunction.
ESC Heart Fail. 2020 Oct;7(5):2123-2134. doi: 10.1002/ehf2.12915. Epub 2020 Jul 25.
8
Research Priorities for Heart Failure With Preserved Ejection Fraction: National Heart, Lung, and Blood Institute Working Group Summary.
Circulation. 2020 Mar 24;141(12):1001-1026. doi: 10.1161/CIRCULATIONAHA.119.041886. Epub 2020 Mar 23.
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Myocardial titin hypophosphorylation importantly contributes to heart failure with preserved ejection fraction in a rat metabolic risk model.
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