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Cracking the Code of a Preclinical Rodent Model of HFpEF: The Mitochondrial Link.

作者信息

Ha Chae-Myeong, Wende Adam R

机构信息

Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.

出版信息

JACC Basic Transl Sci. 2025 Aug 11;10(9):101357. doi: 10.1016/j.jacbts.2025.101357.

DOI:10.1016/j.jacbts.2025.101357
PMID:40795752
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12358656/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc6c/12358656/f7421965670f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc6c/12358656/167f9d245e3d/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc6c/12358656/f7421965670f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc6c/12358656/167f9d245e3d/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc6c/12358656/f7421965670f/gr1.jpg

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本文引用的文献

1
Integrated Systems Biology Identifies Disruptions in Mitochondrial Function and Metabolism as Key Contributors to HFpEF.整合系统生物学确定线粒体功能和代谢紊乱是射血分数保留的心力衰竭的关键促成因素。
JACC Basic Transl Sci. 2025 Aug 15;10(9):101334. doi: 10.1016/j.jacbts.2025.101334.
2
Myocardial Proteome in Human Heart Failure With Preserved Ejection Fraction.射血分数保留的人心力衰竭中的心肌蛋白质组
J Am Heart Assoc. 2025 Mar 18;14(6):e038945. doi: 10.1161/JAHA.124.038945. Epub 2025 Mar 13.
3
Myocardial Metabolomics of Human Heart Failure With Preserved Ejection Fraction.
射血分数保留的心力衰竭的心肌代谢组学。
Circulation. 2023 Apr 11;147(15):1147-1161. doi: 10.1161/CIRCULATIONAHA.122.061846. Epub 2023 Mar 1.
4
Genomic, Proteomic, and Metabolic Comparisons of Small Animal Models of Heart Failure With Preserved Ejection Fraction: A Tale of Mice, Rats, and Cats.心力衰竭保留射血分数的小动物模型的基因组学、蛋白质组学和代谢比较：老鼠、大鼠和猫的故事。
J Am Heart Assoc. 2022 Aug 2;11(15):e026071. doi: 10.1161/JAHA.122.026071. Epub 2022 Jul 29.
5
Global burden of heart failure: a comprehensive and updated review of epidemiology.心力衰竭的全球负担：流行病学的全面更新综述
Cardiovasc Res. 2023 Jan 18;118(17):3272-3287. doi: 10.1093/cvr/cvac013.
6
Myocardial Gene Expression Signatures in Human Heart Failure With Preserved Ejection Fraction.心肌基因表达特征在射血分数保留的心力衰竭患者中。
Circulation. 2021 Jan 12;143(2):120-134. doi: 10.1161/CIRCULATIONAHA.120.050498. Epub 2020 Oct 29.
7
ZSF1 rat as animal model for HFpEF: Development of reduced diastolic function and skeletal muscle dysfunction.ZSF1 大鼠作为 HFpEF 的动物模型：舒张功能障碍和骨骼肌功能障碍的发展。
ESC Heart Fail. 2020 Oct;7(5):2123-2134. doi: 10.1002/ehf2.12915. Epub 2020 Jul 25.
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Research Priorities for Heart Failure With Preserved Ejection Fraction: National Heart, Lung, and Blood Institute Working Group Summary.射血分数保留的心力衰竭研究重点：美国国立心肺血液研究所工作组总结。
Circulation. 2020 Mar 24;141(12):1001-1026. doi: 10.1161/CIRCULATIONAHA.119.041886. Epub 2020 Mar 23.
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Myocardial titin hypophosphorylation importantly contributes to heart failure with preserved ejection fraction in a rat metabolic risk model.肌联蛋白低磷酸化在代谢风险大鼠模型心力衰竭伴射血分数保留中起着重要作用。
Circ Heart Fail. 2013 Nov;6(6):1239-49. doi: 10.1161/CIRCHEARTFAILURE.113.000539. Epub 2013 Sep 6.