Palin Victoria, Brown Oliver, Hamilton Fergus, Lillie Patrick, Kearney Mark, Cubbon Richard, Drozd Michael
Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, UK.
Infection Sciences, North Bristol NHS Trust, Bristol, UK.
Clin Med (Lond). 2025 Aug 10;25(5):100497. doi: 10.1016/j.clinme.2025.100497.
Infections are a major cause of morbidity and mortality in people with heart failure, accounting for approximately 25% of hospitalisations and deaths. Infection hospitalisations in people with heart failure last twice as long as other hospitalisations, with mortality rates after discharge being comparable to those seen after acute decompensated heart failure. Addressing this major challenge is essential to further improving the survival and quality of life of this population. However, very few studies have sought to understand why people with heart failure are predisposed to adverse infection outcomes and there are currently very few interventions that target this problem. In this review, we explore the underlying factors that may predispose individuals with heart failure to infection, highlight the impact of infections on outcomes, explore the potential strategies that may reduce adverse infection outcomes, and highlight future research priorities.
感染是心力衰竭患者发病和死亡的主要原因，约占住院和死亡人数的25%。心力衰竭患者因感染住院的时间是其他住院患者的两倍，出院后的死亡率与急性失代偿性心力衰竭后的死亡率相当。应对这一重大挑战对于进一步提高该人群的生存率和生活质量至关重要。然而，很少有研究试图了解心力衰竭患者易发生不良感染结局的原因，目前针对这一问题的干预措施也非常少。在本综述中，我们探讨了可能使心力衰竭患者易发生感染的潜在因素，强调了感染对结局的影响，探索了可能减少不良感染结局的潜在策略，并突出了未来的研究重点。
