Al-Hourani Khalid, Gill Saran Singh, Govardhana Bhargava Ram, Hurley Eoghan, Khan Shehzaad, Davidson Alastair, Li Xinning, Murray Iain R, Haddad Fares S
Frimley Knee Unit, Frimley Health NHS Foundation Trust, Frimley, UK.
Imperial College London Medical School, London, UK.
Bone Jt Open. 2025 Aug 13;6(8):933-943. doi: 10.1302/2633-1462.68.BJO-2025-0080.R1.
To conduct a scoping review into the use of allograft in primary anterior cruciate ligament (ACL) reconstruction, and to ascertain the variability in reporting outcomes in the literature.
The study was conducted in line with the Preferred Reporting Items for Systematic reviews and Meta-Analayses (PRISMA), and also used Arksey and O'Malley's established five-stage process for scoping reviews in order to map the literature for allograft use in primary ACL reconstruction. Following screening to identify eligible studies, data were extracted and mapped to provide a descriptive and thematic analysis.
A total of 421 studies were identified from the initial search, with 77 studies eligible for final scoping review published from January 1993 to December 2024. The majority of studies were published from the USA and China (56/77, 72.3%). Nine studies (9/77, 11.7%) were level1 evidence. Key variables such as graft diameter (27/77, 33.8%), graft processing (27/77, 35.1%), and cost of graft (3/77, 3.9%) were significantly under-reported. For clinical outcomes, the Lachman score (45/77, 57.1%), pivot shift grade (45/77, 58.4%), and graft re-rupture rate (42/77, 54.5%) were highest reported. For functional outcomes, two predominant scores were recorded, the International Knee Documentation Committee score (52/77, 67.5%) and the Tegner-Lysholm knee score (48/77, 62.3%). A total of 30 functional outcomes were recorded, spanning all studies.
This scoping review identified 77 studies which analyzed allografts in primary ACL reconstruction. There is great variability in the reporting standards, with significant under-reporting of important variables. Further research is required to develop standardized reporting criteria in order to accurately reflect the outcomes of allografts in primary ACL reconstruction.
对同种异体移植物在初次前交叉韧带(ACL)重建中的应用进行范围综述,并确定文献中报告结果的变异性。
本研究按照系统评价和Meta分析的首选报告项目(PRISMA)进行,同时采用了阿克西和奥马利既定的范围综述五阶段流程,以梳理有关同种异体移植物在初次ACL重建中应用的文献。在筛选确定符合条件的研究后,提取数据并进行梳理以提供描述性和主题分析。
通过初步检索共识别出421项研究,其中77项研究符合最终范围综述的条件,这些研究发表于1993年1月至2024年12月。大多数研究来自美国和中国(56/77,72.3%)。9项研究(9/77,11.7%)为1级证据。关键变量如移植物直径(27/77,33.8%)、移植物处理(27/77,35.1%)和移植物成本(3/77,3.9%)的报告明显不足。对于临床结果,Lachman评分(45/77,57.1%)、轴移分级(45/77,58.4%)和移植物再断裂率(42/77,54.5%)的报告最多。对于功能结果,记录了两个主要评分,即国际膝关节文献委员会评分(52/77,67.5%)和Tegner-Lysholm膝关节评分(48/77,62.3%)。所有研究共记录了30项功能结果。
本范围综述确定了77项分析同种异体移植物在初次ACL重建中的研究。报告标准存在很大差异,重要变量的报告明显不足。需要进一步研究以制定标准化报告标准,以便准确反映同种异体移植物在初次ACL重建中的结果。