Runge V M, Clanton J A, Wehr C J, Partain C L, James A E
Magn Reson Imaging. 1985;3(3):255-66. doi: 10.1016/0730-725x(85)90355-8.
ECG gated magnetic resonance images were obtained in six canines prior to and immediately following occlusion of either the LAD or circumflex coronary artery using a surgically placed snare. Multiecho and single-echo acquisition techniques were utilized 0.25 mmol/kg Gd DTPA was injected as an IV bolus 1 hr following coronary artery ligation. In two animals, the region of ischemic myocardium was clearly visualized on multiecho technique without the use of intravenous contrast. The ischemic zone could be best identified on images with a long TE of 120 msec. Contrast enhancement with Gd DTPA enabled visualization of the ischemic myocardium in all six canines. Administration of Gd DTPA, a perfusion agent, improved both detectability and definition of the myocardial lesions.
在6只犬中，使用手术放置的圈套器在结扎左前降支（LAD）或回旋支冠状动脉之前及之后立即获取心电图门控磁共振图像。采用多回波和单回波采集技术，冠状动脉结扎1小时后静脉推注0.25 mmol/kg钆喷替酸葡甲胺（Gd DTPA）。在2只动物中，未使用静脉造影剂的情况下，多回波技术清晰显示了缺血心肌区域。缺血区在120毫秒长TE的图像上识别效果最佳。Gd DTPA造影增强使所有6只犬的缺血心肌均能被观察到。灌注剂Gd DTPA的使用提高了心肌病变的可检测性和清晰度。
