Rehr R B, Peshock R M, Malloy C R, Keller A M, Parkey R W, Buja L M, Nunnally R L, Willerson J T
Am J Cardiol. 1986 Apr 1;57(10):864-8. doi: 10.1016/0002-9149(86)90628-4.
Gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA), a paramagnetic relaxation agent, has been used in vitro to improve the detection of acute myocardial infarction (MI) by magnetic resonance imaging (MRI). In this study, the ability of Gd-DTPA to improve in vivo magnetic resonance imaging of MI was examined. Ten dogs with MI caused by left anterior descending coronary artery ligation were imaged 1 to 5 days after infarction. Imaging was performed before and for 2 hours after intravenous administration of 0.34 mmol/kg Gd-DTPA. One to 2 days after MI, Gd-DTPA improved visualization of the infarct in 3 of 4 dogs. This effect was more prominent in dogs imaged 4 to 5 days after MI, when 6 of 6 dogs showed substantially improved infarct definition after Gd-DTPA. At both times the intensity ratio, an objective measure of contrast between infarcted and normal tissue that is defined by the ratio of image intensity of infarcted area to that of noninfarcted area, was significantly better after Gd-DTPA administration. The intensity ratio at 24 to 48 hours after infarction was 1.4 +/- 0.2 (mean +/- standard deviation) before Gd-DTPA, and 1.7 +/- 0.6 after Gd-DTPA (p = 0.03). The intensity ratio at 4 to 5 days after infarction was 1.5 +/- 0.3 before Gd-DTPA, and 1.8 +/- 0.5 after Gd-DTPA (p less than 0.001). Thus, Gd-DTPA administration improves in vivo visualization of MI by MRI.
钆二乙三胺五乙酸（Gd-DTPA），一种顺磁性弛豫剂，已在体外用于通过磁共振成像（MRI）改善急性心肌梗死（MI）的检测。在本研究中，检测了Gd-DTPA改善MI体内磁共振成像的能力。对10只因左前降支冠状动脉结扎导致MI的犬在梗死后1至5天进行成像。在静脉注射0.34 mmol/kg Gd-DTPA之前和之后2小时进行成像。MI后1至2天，Gd-DTPA改善了4只犬中3只犬梗死灶的可视化。这种效果在MI后4至5天成像的犬中更明显，此时6只犬中有6只在给予Gd-DTPA后梗死灶清晰度显著提高。在这两个时间点，强度比（一种通过梗死区域与非梗死区域图像强度之比定义的梗死组织与正常组织之间对比度的客观测量指标）在给予Gd-DTPA后均显著改善。梗死后24至48小时，Gd-DTPA给药前强度比为1.4±0.2（平均值±标准差），给药后为1.7±0.6（p = 0.03）。梗死后4至5天，Gd-DTPA给药前强度比为1.5±0.3，给药后为1.8±0.5（p＜0.001）。因此，给予Gd-DTPA可通过MRI改善MI的体内可视化。
