帕金森病中人际绩效监测的行为和皮层电活动标志物的多巴胺能调节

Dopaminergic modulation of behavioral and electrocortical markers of interpersonal performance monitoring in Parkinson's Disease.

作者信息

Era Vanessa, Pesci Ugo Giulio, Moreau Quentin, Pezzetta Rachele, Zabberoni Silvia, Peppe Antonella, Costa Alberto, Taglieri Sara, Candidi Matteo, Aglioti Salvatore Maria

机构信息

Department of Psychology, Sapienza University, Rome, Italy.

IRCCS Fondazione Santa Lucia, Rome, Italy.

出版信息

Commun Biol. 2025 Aug 12;8(1):1195. doi: 10.1038/s42003-025-08638-z.

DOI:10.1038/s42003-025-08638-z

PMID:40797097

Abstract

Effective interpersonal interactions necessitate constant monitoring of others' actions, a process known as interpersonal performance monitoring, which is influenced by the dopaminergic system and characterized by specific electrocortical signatures. To examine how this process is affected in Parkinson's Disease (PD), we assess patients with PD performing coordination tasks with a virtual partner (VP) under two conditions: on dopaminergic medication (PD ON) and after withdrawal (PD OFF). During Interactive trials, which require adaptation to the VP's actions, PD OFF performance is impaired compared to PD ON. Electroencephalography (EEG) analysis reveals in PD OFF increased midfrontal Delta-Theta activity during Interactive trials. Multivariate EEG analysis distinguishes Interactive from Cued trials, especially in PD OFF. Our findings highlight the role of dopamine in modulating electrocortical markers of interpersonal performance monitoring, with significant implications for understanding and treating PD.

摘要

有效的人际互动需要持续监测他人的行为，这一过程称为人际绩效监测，它受多巴胺能系统影响，并具有特定的脑电特征。为了研究帕金森病（PD）患者的这一过程是如何受到影响的，我们评估了PD患者在两种情况下与虚拟伙伴（VP）执行协调任务的情况：服用多巴胺能药物时（PD ON）和停药后（PD OFF）。在需要适应VP动作的互动试验中，与PD ON相比，PD OFF的表现受损。脑电图（EEG）分析显示，在互动试验期间，PD OFF患者额中Delta-Theta活动增加。多变量EEG分析区分了互动试验和提示试验，尤其是在PD OFF患者中。我们的研究结果突出了多巴胺在调节人际绩效监测的脑电标记物中的作用，对理解和治疗PD具有重要意义。