Zhu Feng-Lei, Ji Yue, Wang Lu, Xu Min, Zou Xiao-Bing
Child Developmental and Behavioral Center, the Third Affiliated Hospital of Sun Yat- sen University, Guangzhou, China.
J Neurodev Disord. 2025 Aug 12;17(1):47. doi: 10.1186/s11689-025-09636-2.
Although experienced clinicians are capable of diagnosing autism in children before they reach the age of 2, the average age of diagnosis reported internationally is between 4 and 5 years, indicating a significant delay. This study aimed to determine the factors influencing the diagnostic delay time (DDT) in Chinese autistic children.
We employed the Cox proportional hazard model to examine the effects of individual, family, sociodemographic, and healthcare system indicators on DDT in 480 Chinese autistic children (age range: 16.10-190.16 months; male-to-female ratio: 5.67:1) recruited from a tertiary hospital between 2021 and 2023.
The median DDT was 9.58 months (IQR = 15.01). Independent risk factors for delayed diagnosis included normal language competence (RR = 1.747, p < 0.001), non-core symptoms as first concerns (RR = 1.642, p = 0.013), school attendance (RR = 1.941, p < 0.001), irregular well-child visits (RR = 1.264, p = 0.028), and misdiagnosis history (RR = 0.648, p = 0.001).
Diagnosis delay in Chinese autistic children is heterogeneous. Early monitoring for children with normal language skills and school-aged children, alongside improved healthcare system practices, is critical.
尽管经验丰富的临床医生能够在儿童2岁之前诊断出自闭症,但国际上报告的平均诊断年龄在4至5岁之间,这表明存在显著延迟。本研究旨在确定影响中国自闭症儿童诊断延迟时间(DDT)的因素。
我们采用Cox比例风险模型,研究个体、家庭、社会人口统计学和医疗保健系统指标对2021年至2023年期间从一家三级医院招募的480名中国自闭症儿童(年龄范围:16.10 - 190.16个月;男女比例:5.67:1)DDT的影响。
DDT的中位数为9.58个月(IQR = 15.01)。诊断延迟的独立风险因素包括语言能力正常(RR = 1.747,p < 0.001)、首先关注非核心症状(RR = 1.642,p = 0.013)、上学(RR = 1.941,p < 0.001)、儿童健康检查不规律(RR = 1.264,p = 0.028)以及误诊史(RR = 0.648,p = 0.001)。
中国自闭症儿童的诊断延迟情况存在异质性。对语言能力正常的儿童和学龄儿童进行早期监测,同时改善医疗保健系统的做法至关重要。