Wanasitchaiwat Ornnat, Surasereewong Supitchaya, Supapueng Orawan, Panchalee Tachjaree, Moungmaithong Sakita
Department of Obstetrics and Gynaecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.
Division of Clinical Epidemiology, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
BMC Pregnancy Childbirth. 2025 Aug 12;25(1):840. doi: 10.1186/s12884-025-07993-3.
To establish nomograms of anterior cerebral artery (ACA) Doppler indices during 11-13 weeks of gestation.
A descriptive cross-sectional study was conducted on low-risk singleton pregnancies with healthy fetuses. The ACA Doppler spectral waveforms were obtained using transabdominal Doppler sonography, in the same plane as the nuchal translucency measurement. The normative data were analyzed and constructed for the 5th, 10th, 50th, 90th, and 95th percentiles of ACA Doppler indices during 11-13 weeks of gestation.
A total of 216 low-risk singleton pregnancies with healthy fetuses were enrolled in this study; 12 pregnancies were excluded due to duplicating data, affected fetuses by Thalassemia disease, abortion, fetal structural anomalies, fetal growth abnormalities, or uninformed or unrevealed underlying medical conditions. Anterior cerebral artery Doppler was measured, and the nomograms for ACA Doppler indices (ACA-PI, ACA-RI, and ACA-PSV), including the 5th, 10th, 50th, 90th, and 95th percentiles during the gestational period of 11-13 weeks, were established. The range of 5th - 95th percentile of ACA-PI, ACA-RI and ACA-PSV during 11 weeks of gestation were 1.15-1.86, 0.65-0.82 and 6.76-14.40, respectively, during 12 weeks of gestation were 1.22-1.90, 0.65-0.88 and 7.09-15.03, respectively and during 13 weeks of gestation were 1.26-1.82, 0.67-0.84 and 7.69-17.40, respectively.
During 11-13 weeks of gestation, the ACA-PI and ACA-RI values remained relatively constant, while PSV values gradually increased with gestation.
建立妊娠11至13周期间大脑前动脉（ACA）多普勒指数的列线图。
对低风险单胎健康胎儿妊娠进行描述性横断面研究。使用经腹多普勒超声在与颈部半透明测量相同的平面上获取ACA多普勒频谱波形。对妊娠11至13周期间ACA多普勒指数的第5、第10、第50、第90和第95百分位数的规范数据进行分析并构建。
本研究共纳入216例低风险单胎健康胎儿妊娠；12例妊娠因数据重复、胎儿受地中海贫血病影响、流产、胎儿结构异常、胎儿生长异常或潜在医疗状况未告知或未披露而被排除。测量大脑前动脉多普勒，并建立了11至13周妊娠期ACA多普勒指数（ACA-PI、ACA-RI和ACA-PSV）的列线图，包括第5、第10、第50、第90和第95百分位数。妊娠11周时，ACA-PI、ACA-RI和ACA-PSV的第5至第95百分位数范围分别为1.15至1.86、0.65至0.82和6.76至14.40；妊娠12周时分别为1.22至1.90、0.65至0.88和7.09至15.03；妊娠13周时分别为1.26至1.82、0.67至0.84和7.69至17.40。
在妊娠11至13周期间，ACA-PI和ACA-RI值保持相对恒定，而PSV值随妊娠逐渐增加。
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