Sahin Nazli Ece, Alici Davutoglu Ebru, Arica Gorkem, Madazli Riza
Cerrahpasa Medical Faculty, Department of Obstetrics and Gynecology, Istanbul University-Cerrahpasa, Kocamustafapasa, Istanbul, Turkey.
Cerrahpasa Medical Faculty, Department of Obstetrics and Gynecology, Division of Perinatology, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Arch Gynecol Obstet. 2025 May 23. doi: 10.1007/s00404-025-08061-z.
To establish nomograms for the bilateral fornix-hippocampus complex (FHC) length and hippocampus height (HH) in fetuses between 18 + 0 and 36 + 0 weeks of gestation using two-dimensional (2D) sonography and assess potential laterality differences.
A prospective study was conducted on 725 singleton pregnancies at the Maternal-Fetal Medicine Department from January to December 2024. Gestational age was confirmed via first-trimester crown-rump length measurements. Exclusion criteria included maternal chronic diseases, multiple pregnancies, fetal anomalies, and growth restriction. Transabdominal 2D sonography captured FHC and HH measurements in the parasagittal plane. Laterality was determined before imaging, and each measurement was repeated twice for reliability. Percentiles (5th, 50th, and 95th) were calculated, and Pearson correlation coefficients assessed relationships with gestational age. The independent samples t-test compared left and right measurements, and intraobserver reliability was evaluated with the intraclass correlation coefficient (ICC).
Nomograms with 5th, 50th, and 95th percentiles were established for both sides. The Pearson correlation coefficients for the left and right sides of the FHC length and HH with advancing gestational age were 0.808, 0.808, 0.725, and 0.734, respectively. The correlation coefficients between FHC length and HH for the left and right sides were 0.814 and 0.818, respectively. No significant laterality differences were found (p > 0.05).
These nomograms provide reference data for assessing fetal neurodevelopment. They may aid in detecting abnormalities, particularly in corpus callosum agenesis and ventriculomegaly.
使用二维超声建立孕18⁺⁰至36⁺⁰周胎儿双侧穹窿 - 海马复合体（FHC）长度和海马高度（HH）的列线图，并评估潜在的左右侧差异。
2024年1月至12月在母胎医学科对725例单胎妊娠进行了一项前瞻性研究。通过孕早期头臀长度测量确定孕周。排除标准包括母亲慢性疾病、多胎妊娠、胎儿畸形和生长受限。经腹二维超声在矢状旁平面获取FHC和HH测量值。在成像前确定左右侧，每个测量值重复两次以确保可靠性。计算百分位数（第5、50和95百分位数），并通过Pearson相关系数评估与孕周的关系。独立样本t检验比较左右测量值，观察者内可靠性用组内相关系数（ICC）评估。
建立了两侧第5、50和95百分位数的列线图。FHC长度和HH的左侧和右侧与孕周增加的Pearson相关系数分别为0.808、0.808、0.725和0.734。左侧和右侧FHC长度与HH之间的相关系数分别为0.814和0.818。未发现明显的左右侧差异（p>0.05）。
这些列线图为评估胎儿神经发育提供了参考数据。它们可能有助于检测异常情况，特别是胼胝体发育不全和脑室扩大。
