Wang Meixia, Wang Xiaofang, Deng Haiyun, Liu Xue, Xv Min
Obstetrics Department, The Fourth Hospital of Shijiazhuang (Shijiazhuang Obstetrics and Gynecology Hospital), Shijiazhuang City, Hebei Province, China.
Medicine (Baltimore). 2025 Aug 8;104(32):e43509. doi: 10.1097/MD.0000000000043509.
Infectious preterm delivery is a serious health problem in pregnant women. The pathogenesis of infectious preterm delivery is associated with the alterations of Toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)/nuclear factor κB (NF-κB) and other inflammatory factors. This study investigates the correlation of TLR4/MyD88/NF-κB and inflammatory factors with infectious preterm labor in pregnant women. A total of 200 preterm delivery parturients admitted to our hospital were retrospectively selected as research subjects, including 100 infected preterm delivery parturients (infected group) and 100 noninfected preterm delivery parturients (noninfected group), while the control group included 100 normal full-term parturients. In order to analyze the clinical value of these indexes in predicting infectious preterm delivery, a receiver operating characteristic curve was used. The levels of TLR4/MyD88/NF-κB, interleukin-1β, C-reactive protein, tumor necrosis factor-α (TNF-α), and interleukin-6 in infected group were significantly higher than those in noninfected group and control group (P < .05). Based on receiver operating characteristic curve analysis, it was found that the area under curve of TLR4/MyD88/NF-κB for diagnosing infectious preterm delivery were 0.771, 0.846, and 0.789, respectively. Changes in interleukin-6 levels and TLR4/MyD88/NF-κB may reflect the risk of infectious preterm delivery in pregnant women to some extent.
感染性早产是孕妇面临的一个严重健康问题。感染性早产的发病机制与Toll样受体4（TLR4）/髓样分化因子88（MyD88）/核因子κB（NF-κB）及其他炎症因子的改变有关。本研究探讨TLR4/MyD88/NF-κB和炎症因子与孕妇感染性早产的相关性。回顾性选取我院收治的200例早产产妇作为研究对象，其中感染性早产产妇100例（感染组），非感染性早产产妇100例（非感染组），对照组为100例正常足月产妇。为分析这些指标在预测感染性早产中的临床价值，采用了受试者工作特征曲线。感染组TLR4/MyD88/NF-κB、白细胞介素-1β、C反应蛋白、肿瘤坏死因子-α（TNF-α）和白细胞介素-6水平显著高于非感染组和对照组（P<0.05）。基于受试者工作特征曲线分析，发现TLR4/MyD88/NF-κB诊断感染性早产的曲线下面积分别为0.771、0.846和0.789。白细胞介素-6水平和TLR4/MyD88/NF-κB的变化在一定程度上可能反映孕妇感染性早产的风险。
