Wu Haihua, Yin Dan, Ma Chenyang, Chen Xiufang
Department of Rheumatology, Jiangnan Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China.
Department of Internal Medicine, The Second People's Hospital, Hangzhou, China.
Medicine (Baltimore). 2025 Aug 8;104(32):e43667. doi: 10.1097/MD.0000000000043667.
This study analyzes the platelet-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and mean platelet volume (MPV) in the evaluation of disease activity in patients with rheumatoid arthritis (RA). The clinical data of patients with RA and healthy controls, including complete blood count, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), anti-cyclic citrullinated peptide antibody (anti-CCP antibody), and rheumatoid factor (RF), were retrospectively analyzed. The SII, PLR, and MPV were collected and calculated for the RA. Pearson correlation analysis was used to estimate the correlation between hematological indices and DAS28-ESR. Receiver-operating characteristic (ROC) curve analysis was performed to assess the value of these indices in differentiating active RA from RA remission. The results revealed that SII and PLR were elevated and MPV was markedly decreased in patients with RA compared to healthy controls (all P < .05). Statistical significance was observed in SII and MPV, but not in PLR, between the active RA patients and the remission RA group. SII and PLR were positively correlated with DAS28-ESR and DAS28-CRP, whereas MPV was negatively correlated with DAS28-CRP but not with DAS28-ESR. The ROC curve showed that the SII and MPV were helpful in assessing disease activity in RA. SII and MPV were correlated with the DAS28 score and may be used as complementary tools to evaluate disease activity in patients with RA.
本研究分析了血小板-淋巴细胞比值（PLR）、全身免疫炎症指数（SII）和平均血小板体积（MPV）在评估类风湿关节炎（RA）患者疾病活动度中的作用。对RA患者和健康对照者的临床资料进行回顾性分析，包括全血细胞计数、C反应蛋白（CRP）、红细胞沉降率（ESR）、抗环瓜氨酸肽抗体（抗CCP抗体）和类风湿因子（RF）。收集并计算RA患者的SII、PLR和MPV。采用Pearson相关性分析评估血液学指标与DAS28-ESR之间的相关性。进行受试者操作特征（ROC）曲线分析，以评估这些指标在区分活动期RA与缓解期RA中的价值。结果显示，与健康对照者相比，RA患者的SII和PLR升高，MPV显著降低（均P < 0.05）。活动期RA患者与缓解期RA组之间，SII和MPV有统计学意义，但PLR无统计学意义。SII和PLR与DAS28-ESR和DAS28-CRP呈正相关，而MPV与DAS28-CRP呈负相关，但与DAS28-ESR无相关性。ROC曲线显示，SII和MPV有助于评估RA的疾病活动度。SII和MPV与DAS28评分相关，可作为评估RA患者疾病活动度的补充工具。
