Hou Yan, Cai Weilun, Xu Hua, Ban Jiandong
Department of Stomatology, Hebei Eye Hospital, Xingtai, China.
Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Medicine (Baltimore). 2025 Aug 8;104(32):e43700. doi: 10.1097/MD.0000000000043700.
The aim of this study was to assess the causal association between age at menarche (AAM) and periodontitis by use of a 2-sample 2-way Mendelian randomization (MR) study. A 2-sample bidirectional MR analysis was performed based on genome-wide association study data from European populations of AAM and chronic periodontitis, using single nucleotide polymorphisms as instrumental variables. Inverse-variance weighting, weighted median, weighted multinomial, and MR-Egger were used to assess the bidirectional causal association between AAM and chronic periodontitis. The inverse-variance weighting method showed a significant negative correlation between genetically predicted AAM and chronic periodontitis (odds ratio: 0.733; 95% confidence interval: 0.583-0.922; P = .0081), Cochran Q test showed no heterogeneity, MR-Egger showed there was no pleiotropic, leave-one-out confirmed the robustness of the results, and reverse MR analysis demonstrated no reverse causality. AAM may be negatively associated with chronic periodontitis.
本研究旨在通过使用两样本双向孟德尔随机化（MR）研究来评估初潮年龄（AAM）与牙周炎之间的因果关系。基于欧洲人群中AAM和慢性牙周炎的全基因组关联研究数据，以单核苷酸多态性作为工具变量进行了两样本双向MR分析。采用逆方差加权法、加权中位数法、加权多项式法和MR-Egger法来评估AAM与慢性牙周炎之间的双向因果关系。逆方差加权法显示，基因预测的AAM与慢性牙周炎之间存在显著负相关（优势比：0.733；95%置信区间：0.583-0.922；P = 0.0081），Cochran Q检验显示无异质性，MR-Egger法显示无多效性，留一法证实了结果的稳健性，反向MR分析表明无反向因果关系。AAM可能与慢性牙周炎呈负相关。
