Mowafy T K, el-Serafy A K, Abd el-Hady S L, Atallah M M
Middle East J Anaesthesiol. 1985 Oct;8(3):215-22.
Eighteen adult white rats were divided into 3 groups, 6 rats each (two males and four females). The first group was exposed to 1.5% halothane for 20 minutes, every other day for 6 exposures. The rats were mated and exposed for another 10 exposures. The second group was given 0.1% phenobarbitone in milk starting one week before and during the period of exposure, which was similar to the first group. The third group was kept as a control. At the suspected date of delivery, the rats were sacrificed and specimens were taken from the mother's liver for estimation of the activities of the enzymes succinate dehydrogenase, acid phosphatase and alkaline phosphatase. Repeated halothane exposure decreased the activity of the enzymes succinate dehydrogenase, acid phosphatase and alkaline phosphatase. Treatment with phenobarbitone has the same effect on succinate dehydrogenase, but partially spared the activities of acid and alkaline phosphatases.
18只成年白鼠被分成3组，每组6只（2只雄性和4只雌性）。第一组每隔一天暴露于1.5%的氟烷中20分钟，共暴露6次。这些大鼠交配后再暴露10次。第二组在暴露前一周开始并在暴露期间给予含0.1%苯巴比妥的牛奶，暴露情况与第一组相似。第三组作为对照组。在预计分娩日期，处死大鼠并从母鼠肝脏取材，以测定琥珀酸脱氢酶、酸性磷酸酶和碱性磷酸酶的活性。反复暴露于氟烷会降低琥珀酸脱氢酶、酸性磷酸酶和碱性磷酸酶的活性。苯巴比妥处理对琥珀酸脱氢酶有相同作用，但部分保留了酸性和碱性磷酸酶的活性。
