Atallah M M, el-Serafy A K, Abd el-Hady S L, Mowafy T K
Middle East J Anaesthesiol. 1985 Oct;8(3):207-14.
Adult white rats were divided into 3 groups; 6 rats each, (two males and four females). Group I was exposed to 1.5% halothane for 20 minutes every other day for 6 exposures. The rats were mated and exposed another 10 exposures. Group II was given 0.1% phenobarbitone in milk one week before, and during the period of exposure to halothane which was similar to the first group. Group III was kept as a control. At the suspected date of delivery, the rats were sacrificed, and specimens were taken from the liver for hematoxylin and eosin stain, PAS reaction and Sudan black stain. Repeated exposure to halothane did not affect the pregnancy rate, but it resulted in hepatic focal and centrilobular necrosis with glycogen poverty and moderate lipid content. The portal spaces showed thick connective tissue and lymphocytic infiltration. Phenobarbitone reduced the pregnancy rate and resulted in 16.5% fetal mortality with more hepatic necrosis and increase in glycogen and lipid content.
成年白鼠被分为3组，每组6只（2只雄性和4只雌性）。第一组每隔一天暴露于1.5%的氟烷中20分钟，共暴露6次。这些大鼠交配后又进行了10次暴露。第二组在暴露于与第一组相似的氟烷之前一周以及暴露期间，给予含0.1%苯巴比妥的牛奶。第三组作为对照。在预计分娩日期，处死大鼠，取肝脏标本进行苏木精-伊红染色、PAS反应和苏丹黑染色。反复暴露于氟烷不影响妊娠率，但导致肝灶性和小叶中心坏死，糖原缺乏且脂质含量中等。门管区显示结缔组织增厚和淋巴细胞浸润。苯巴比妥降低了妊娠率，导致16.5%的胎儿死亡，肝坏死更多，糖原和脂质含量增加。
