Mahjoob Mohammad Parsa, HajiAghajani Mohammad, Mohamadizadeh Nafiseh, Sadeghi Roxana, Heidari Amir, Omidi Fatemeh, Taherpour Niloufar, Fazlekhoda Morteza
Prevention of Cardiovascular Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Tracheal Diseases Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Catheter Cardiovasc Interv. 2025 Aug 12. doi: 10.1002/ccd.70083.
Premature coronary artery disease (PCAD), defined as > 50% coronary artery stenosis in men < 55 years and women < 65 years, is an escalating public health issue. The role of testosterone as a risk or protective factor remains debated. This study investigated the association between serum testosterone levels and PCAD in young adult males.
To investigate the association between serum testosterone levels and premature coronary artery disease (PCAD) in young adult males undergoing coronary angiography.
This case-control study enrolled 106 men < 55 years undergoing coronary angiography at Imam Hossein educational hospital (Tehran, Iran) from 2023 to 2024. Participants were divided into two groups: 53 with PCAD (stenosis > 50% in at least one major coronary artery) and 53 with normal coronary arteries. Serum total and free testosterone levels were measured using chemiluminescent immunoassay (CLIA). Anthropometric data, medical history (e.g., hypertension, diabetes), and laboratory parameters were recorded. Statistical analyses included t-tests, Spearman correlation, and logistic regression, with p < 0.05 deemed significant.
The mean age was 43.24 ± 4.98 years, with PCAD patients being older (44.81 ± 4.50 vs. 41.68 ± 4.98 years, p = 0.001). Hypertension (49.06% vs. 28.30%, p = 0.028) and diabetes (28.30% vs. 9.43%, p = 0.013) were more prevalent in the PCAD group. Mean total testosterone was significantly lower in PCAD patients (321.45 ± 154.63 ng/dL) than in controls (437.02 ± 142.81 ng/dL, p < 0.05), as was free testosterone (12.38 ± 8.25 vs. 20.86 ± 8.13 pg/mL, p < 0.05). Multivariable logistic regression, adjusted for age, clinical history, and medication use, showed a 1 pg/mL increase in free testosterone reduced PCAD odds by 13% (OR = 0.87, 95% CI: 0.81-0.94, p < 0.001).
Lower serum testosterone levels are associated with increased PCAD risk in young males. These findings highlight the need for longitudinal studies to explore testosterone's role in PCAD prevention.
早发性冠状动脉疾病（PCAD）定义为55岁以下男性和65岁以下女性冠状动脉狭窄>50%，是一个日益严重的公共卫生问题。睾酮作为风险因素或保护因素的作用仍存在争议。本研究调查了年轻成年男性血清睾酮水平与PCAD之间的关联。
调查接受冠状动脉造影的年轻成年男性血清睾酮水平与早发性冠状动脉疾病（PCAD）之间的关联。
本病例对照研究纳入了2023年至2024年在伊玛目侯赛因教育医院（伊朗德黑兰）接受冠状动脉造影的106名55岁以下男性。参与者分为两组：53例患有PCAD（至少一支主要冠状动脉狭窄>50%）和53例冠状动脉正常者。采用化学发光免疫分析法（CLIA）测量血清总睾酮和游离睾酮水平。记录人体测量数据、病史（如高血压、糖尿病）和实验室参数。统计分析包括t检验、Spearman相关性分析和逻辑回归分析，p<0.05被认为具有统计学意义。
平均年龄为43.24±4.98岁，PCAD患者年龄较大（44.81±4.50岁 vs. 41.68±4.98岁，p=0.001）。高血压（49.06% vs. 28.30%，p=0.028）和糖尿病（28.30% vs. 9.43%，p=0.013）在PCAD组中更为普遍。PCAD患者的平均总睾酮水平（321.45±154.63 ng/dL）显著低于对照组（437.02±142.81 ng/dL，p<0.05），游离睾酮水平也是如此（12.38±8.25 vs. 20.86±8.13 pg/mL，p<0.05）。在对年龄、临床病史和药物使用进行调整的多变量逻辑回归分析中，游离睾酮每增加1 pg/mL，PCAD的患病几率降低13%（OR=0.87，95%CI：0.81-0.94，p<0.001）。
较低的血清睾酮水平与年轻男性PCAD风险增加有关。这些发现凸显了开展纵向研究以探索睾酮在PCAD预防中的作用的必要性。
