Li Jianan, Qu Ying, Chu Bingyang, Wu Tingkui, Pan Meng, Mo Dong, Li Lang, Ming Yang, Yang Yun, Wang Meng, He Xinlong, Qian Zhiyong
Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Department of Hematology and Institute of Hematology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Adv Sci (Weinh). 2025 Sep;12(33):e01209. doi: 10.1002/advs.202501209. Epub 2025 Aug 13.
The immune system plays a pivotal role in bone regeneration, and biomaterials engineered to modulate immune responses present a promising strategy for the treatment of extensive bone defects and osteolytic conditions. This review critically evaluates recent advancements in immunomodulatory biomaterials for bone repair, integrating perspectives from both immunology and materials science. It offers a comprehensive analysis of key design strategies and the underlying principles guiding the development of these biomaterials, with a particular focus on their physical and chemical properties, bioactive molecule delivery systems, cell transplantation techniques, and responses to external stimuli. Additionally, this review examines the interactions between these biomaterials and immune cells, particularly macrophages, within various pathological contexts. Finally, the paper discusses current challenges and future directions, aiming to provide researchers and clinicians with a valuable resource for advancing this rapidly evolving field.
免疫系统在骨再生中起着关键作用，设计用于调节免疫反应的生物材料为治疗大面积骨缺损和溶骨性疾病提供了一种有前景的策略。本综述批判性地评估了用于骨修复的免疫调节生物材料的最新进展，整合了免疫学和材料科学的观点。它全面分析了指导这些生物材料开发的关键设计策略和基本原理，特别关注其物理和化学性质、生物活性分子递送系统、细胞移植技术以及对外部刺激的反应。此外，本综述研究了这些生物材料与各种病理背景下的免疫细胞，特别是巨噬细胞之间的相互作用。最后，本文讨论了当前的挑战和未来的方向，旨在为研究人员和临床医生提供推进这一快速发展领域的宝贵资源。
