Seo Seung-Ho, Kang Sang-Mi, You Yang-Hee, Na Chang-Su
College of Korean Medicine, Dongshin University, 120-9 Dongsindae-gil, Naju, Republic of Korea.
Bone Rep. 2025 Jul 31;26:101864. doi: 10.1016/j.bonr.2025.101864. eCollection 2025 Sep.
This study evaluated the therapeutic effects of 650 nm laser acupuncture at 10 mW and 20 mW in a monosodium iodoacetate (MIA) induced osteoarthritis (OA) rat model. OA was induced by intra-articular injection of MIA, and laser acupuncture was applied to GB34 and GB39 twice weekly for four weeks. Cartilage preservation was assessed by Safranin-O staining, pain by hind paw weight distribution, bone structure by micro-CT analysis of bone volume fraction, trabecular volume, and cortical thickness, and muscle condition by histology and wet weight of the gastrocnemius and quadriceps. Both laser treatments reduced cartilage degeneration and improved weight-bearing. The 10 mW group showed greater improvements than the 20 mW group, including higher proteoglycan content, better bone structural parameters, and greater muscle mass. These results indicate that 10 mW laser acupuncture is more effective than 20 mW in reducing joint damage and preserving musculoskeletal tissue. The findings support the use of low-power laser acupuncture as a non-invasive treatment for OA. The study also shows that higher laser power does not necessarily lead to better outcomes, highlighting the need for appropriate dose selection. Further studies are needed to assess long-term effects and investigate underlying mechanisms.
本研究评估了10毫瓦和20毫瓦的650纳米激光针刺对碘乙酸钠（MIA）诱导的骨关节炎（OA）大鼠模型的治疗效果。通过关节内注射MIA诱导OA，并每周两次对GB34和GB39进行激光针刺，共四周。通过番红O染色评估软骨保存情况，通过后爪重量分布评估疼痛，通过对骨体积分数、小梁体积和皮质厚度进行显微CT分析评估骨结构，通过组织学以及腓肠肌和股四头肌的湿重评估肌肉状况。两种激光治疗均减轻了软骨退变并改善了负重情况。10毫瓦组比20毫瓦组显示出更大的改善，包括更高的蛋白聚糖含量、更好的骨结构参数和更大的肌肉质量。这些结果表明，10毫瓦激光针刺在减少关节损伤和保存肌肉骨骼组织方面比20毫瓦更有效。这些发现支持将低功率激光针刺作为OA的非侵入性治疗方法。该研究还表明，更高的激光功率不一定会带来更好的结果，突出了选择合适剂量的必要性。需要进一步研究来评估长期效果并探究潜在机制。
