ALK 阳性非小细胞肺癌治疗顺序的抉择：洛拉替尼是延长生存期的关键吗？ - Suppr

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Navigating treatment sequencing in ALK-positive non-small cell lung cancer: lorlatinib as a key to prolonged survival?

作者信息

Ulhøi Maiken Parm, Meldgaard Peter

机构信息

Department of Oncology, Aarhus University Hospital (AUH), Aarhus, Denmark.

出版信息

Transl Lung Cancer Res. 2025 Jul 31;14(7):2359-2363. doi: 10.21037/tlcr-2025-373. Epub 2025 Jul 28.

DOI:10.21037/tlcr-2025-373

PMID:40799441

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12337053/

Abstract

摘要

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Final Overall Survival and Long-Term Safety of Lorlatinib in Patients With ALK-Positive NSCLC From the Pivotal Phase 2 Study: A Brief Report.关键2期研究中劳拉替尼治疗ALK阳性非小细胞肺癌患者的最终总生存期和长期安全性：简要报告

J Thorac Oncol. 2025 Apr;20(4):513-520. doi: 10.1016/j.jtho.2024.11.021. Epub 2024 Nov 22.

Lorlatinib-associated weight gain and dyslipidaemia: A retrospective analysis and implications for future care.劳拉替尼相关的体重增加和血脂异常：一项回顾性分析及对未来治疗的启示

Lung Cancer. 2024 Dec;198:108034. doi: 10.1016/j.lungcan.2024.108034. Epub 2024 Nov 19.

Real-World Treatment Patterns and Outcomes Across Three Lines of Therapy in Patients with ALK+ NSCLC.ALK+ NSCLC 患者三线治疗的真实世界治疗模式和结局。

Adv Ther. 2024 Aug;41(8):3217-3231. doi: 10.1007/s12325-024-02899-6. Epub 2024 Jun 25.

Progression patterns, resistant mechanisms and subsequent therapy for ALK-positive NSCLC in the era of second-generation ALK-TKIs.ALK 阳性 NSCLC 二代 ALK-TKIs 时代的进展模式、耐药机制及后续治疗。

J Transl Med. 2024 Jun 20;22(1):585. doi: 10.1186/s12967-024-05388-0.

The Role of Local Therapy for Oligo-Progressive Disease in Oncogene-Addicted Non-Small-Cell Lung Cancer.局部治疗在癌基因成瘾性非小细胞肺癌寡进展性疾病中的作用

Adv Radiat Oncol. 2024 Apr 14;9(7):101516. doi: 10.1016/j.adro.2024.101516. eCollection 2024 Jul.

Lorlatinib Versus Crizotinib in Patients With Advanced -Positive Non-Small Cell Lung Cancer: 5-Year Outcomes From the Phase III CROWN Study.洛拉替尼对比克唑替尼用于治疗晚期 ALK 阳性非小细胞肺癌患者：III 期 CROWN 研究的 5 年结果。

J Clin Oncol. 2024 Oct 10;42(29):3400-3409. doi: 10.1200/JCO.24.00581. Epub 2024 May 31.

Brigatinib Versus Alectinib in ALK-Positive NSCLC After Disease Progression on Crizotinib: Results of Phase 3 ALTA-3 Trial.布加替尼对比阿来替尼用于克唑替尼治疗后进展的 ALK 阳性 NSCLC ：III 期 ALTA-3 试验结果。

J Thorac Oncol. 2023 Dec;18(12):1743-1755. doi: 10.1016/j.jtho.2023.08.010. Epub 2023 Aug 12.

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Clin Lung Cancer. 2023 Jan;24(1):40-50. doi: 10.1016/j.cllc.2022.09.007. Epub 2022 Sep 24.

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