冠心病患者经皮冠状动脉介入治疗后甘油三酯-葡萄糖指数与支架内再狭窄之间呈正线性相关。

A positive linear correlation between the triglyceride-glucose index and in-stent restenosis after percutaneous coronary intervention in patients with coronary heart disease.

作者信息

Mao Jin, Fang Zigen, Jiang Shan, Xia Zeyan

机构信息

Department of Emergency Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.

出版信息

Front Cardiovasc Med. 2025 Jul 29;12:1544125. doi: 10.3389/fcvm.2025.1544125. eCollection 2025.

DOI:10.3389/fcvm.2025.1544125

PMID:40799640

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12339500/

Abstract

AIMS

The association between the triglyceride-glucose (TyG) index and in-stent restenosis (ISR) after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD) remains inadequately explored. This study aimed to evaluate the relationship between TyG and ISR in patients with CHD following PCI.

METHODS

This retrospective study included 519 patients with CHD undergoing PCI. TyG, considered as the exposure variable, was divided into lower (≤9.21) and higher (>9.21) groups based on the optimal cutoff determined by receiver operator characteristic (ROC) analysis, with ISR as the outcome variable. Multivariable logistic regression, subgroup analysis, ROC analysis and restricted cubic spline (RCS) modeling were used to assess the association between TyG and ISR.

RESULTS

Patients with higher TyG had a significantly greater incidence of ISR compared to patients with lower TyG ( = 0.003). Patients with ISR had higher levels of TyG compared with patients without ISR ( = 0.006). In multivariable logistic regression analysis, after adjusting for confounding variables, a higher TyG index was significantly associated with an increased risk of ISR, both as a categorical and a continuous variable [Model 3, OR (95% CI), value: 1.786 (1.134, 2.814), 0.012 and 1.408 (1.034, 1.917), 0.030, respectively]. The association remained significant in subgroups aged < 60 years, male, non-smokers, and those with hypertension ( < 0.05). Additionally, ROC analysis showed that TyG had modest predictive value for ISR (AUC = 0.571, = 0.020), and its addition to the baseline model significantly improved the overall predictive performance (AUC = 0.643, < 0.001). RCS analysis further confirmed a positive linear correlation between TyG and ISR ( = 0.042; for nonlinearity = 0.808).

CONCLUSION

A higher TyG index is significantly associated with an increased risk of ISR in CHD after PCI, highlighting its potential as a valuable biomarker for cardiovascular risk stratification.

摘要

目的

冠心病（CHD）患者经皮冠状动脉介入治疗（PCI）后，甘油三酯-葡萄糖（TyG）指数与支架内再狭窄（ISR）之间的关联仍未得到充分研究。本研究旨在评估冠心病患者PCI术后TyG与ISR之间的关系。

方法

这项回顾性研究纳入了519例行PCI的冠心病患者。将TyG作为暴露变量，根据受试者工作特征（ROC）分析确定的最佳截断值分为较低（≤9.21）和较高（>9.21）两组，以ISR作为结局变量。采用多变量逻辑回归、亚组分析、ROC分析和限制性立方样条（RCS）建模来评估TyG与ISR之间的关联。

结果

与TyG较低的患者相比，TyG较高的患者ISR发生率显著更高（=0.003）。与无ISR的患者相比，有ISR的患者TyG水平更高（=0.006）。在多变量逻辑回归分析中，调整混杂变量后，较高的TyG指数与ISR风险增加显著相关，无论是作为分类变量还是连续变量[模型3，OR（95%CI），值：分别为1.786（1.134，2.814），0.012和1.408（1.034，1.917），0.030]。在年龄<60岁、男性、非吸烟者和高血压患者亚组中，这种关联仍然显著（<0.05）。此外；ROC分析表明，TyG对ISR有中等预测价值（AUC=0.571，=0.020），将其加入基线模型可显著提高总体预测性能（AUC=0.643，<0.001）。RCS分析进一步证实TyG与ISR之间存在正线性相关（=0.042；非线性检验P值=0.808）。