Charbonneau Joey A, Raven Erika P, Katsumi Yuta, Santistevan Anthony C, Taylor Christopher, Bliss-Moreau Eliza
Neuroscience Graduate Program, University of California Davis, Davis, CA, United States.
California National Primate Research Center, University of California Davis, Davis, CA, United States.
Imaging Neurosci (Camb). 2024 Aug 14;2. doi: 10.1162/imag_a_00261. eCollection 2024.
In recent decades,magnetic resonance imaging (MRI) studies have provided previously inaccessible insights into the structure and function of healthy and pathological human brains in the laboratory and the clinic. However, the correlational nature of this work and relatively low resolution mean that ground truth neuroanatomical studies and causal manipulations of neural circuitry must still occur in animal models offering greater tractability and higher resolution, rendering a scale and species gap in translation. Here, we bridge this gap with a detailed, multimodal investigation of the macaque insula. Using both functional and diffusion MRI-tools available for use in humans-we demonstrate a neural architecture in the macaque insula with clear correspondence to priorMRI findings in humans and postmortem cytoarchitectural and tract-tracing studies in monkeys. Results converged across analysis methods and imaging modalities, supporting the translational potential of the macaque model.
近几十年来，磁共振成像（MRI）研究为在实验室和临床环境中了解健康及病变人类大脑的结构与功能提供了前所未有的见解。然而，这项工作的相关性本质以及相对较低的分辨率意味着，真实的神经解剖学研究和对神经回路的因果操纵仍必须在具有更高可操作性和更高分辨率的动物模型中进行，这导致了在转化过程中的规模和物种差距。在此，我们通过对猕猴脑岛进行详细的多模态研究来弥合这一差距。利用可用于人类的功能和扩散MRI工具，我们展示了猕猴脑岛中的一种神经结构，它与先前人类MRI研究结果以及猴子死后细胞结构和神经束追踪研究结果有着明确的对应关系。结果在各种分析方法和成像模态中趋于一致，支持了猕猴模型的转化潜力。
