C. and O. Vogt Institute for Brain Research, Medical Faculty, University Hospital Düsseldorf, Heinrich Heine University of Düsseldorf, Germany; Institute for Anatomy I, Medical Faculty, Heinrich Heine University of Düsseldorf, Germany; Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Germany.
Institute for Anatomy I, Medical Faculty, Heinrich Heine University of Düsseldorf, Germany; Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Germany.
Neuroimage. 2022 Oct 15;260:119453. doi: 10.1016/j.neuroimage.2022.119453. Epub 2022 Jul 6.
The human insular cortex supports multifunctional integration including interoceptive, sensorimotor, cognitive and social-emotional processing. Different concepts of the underlying microstructure have been proposed over more than a century. However, a 3D map of the cytoarchitectonic segregation of the insula in standard reference space, that could be directly linked to neuroimaging experiments addressing different cognitive tasks, is not yet available. Here we analyzed the middle posterior and dorsal anterior insula with image analysis and a statistical mapping procedure to delineate cytoarchitectonic areas in ten human postmortem brains. 3D-probability maps of seven new areas with granular (Ig3, posterior), agranular (Ia1, posterior) and dysgranular (Id2-Id6, middle to dorsal anterior) cytoarchitecture have been calculated to represent the new areas in stereotaxic space. A hierarchical cluster analysis based on cytoarchitecture resulted in three distinct clusters in the superior posterior, inferior posterior and dorsal anterior insula, providing deeper insights into the structural organization of the insula. The maps are openly available to support future studies addressing relations between structure and function in the human insula.
人类脑岛皮层支持多种功能整合，包括内脏感觉、感觉运动、认知和社会情感处理。一个多世纪以来，人们提出了许多关于其潜在微观结构的概念。然而，目前还没有在标准参考空间中对岛叶细胞构筑进行分区的 3D 图谱，该图谱可以直接与解决不同认知任务的神经影像学实验相关联。在这里，我们使用图像分析和统计映射程序分析了十个人体死后大脑的中后和背前部脑岛，以描绘细胞构筑区域。已经计算了七个具有颗粒状（Ig3，后部）、无颗粒状（Ia1，后部）和发育不良颗粒状（Id2-Id6，中到背前部）细胞构筑的新区域的 3D 概率图，以在立体定向空间中表示这些新区域。基于细胞构筑的层次聚类分析导致上后、下后和背前部脑岛的三个不同簇，为脑岛的结构组织提供了更深入的了解。这些图谱可供公开使用，以支持未来研究解决人类脑岛结构与功能之间的关系。
