Boudreau Mathieu, Karakuzu Agah, Boré Arnaud, Pinsard Basile, Zelenkovski Kiril, Alonso-Ortiz Eva, Boyle Julie, Bellec Lune, Cohen-Adad Julien
NeuroPoly, Polytechnique Montreal, Montreal, QC, Canada.
Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal (CRIUGM), Montreal, QC, Canada.
Imaging Neurosci (Camb). 2025 Jan 2;3. doi: 10.1162/imag_a_00409. eCollection 2025.
Quantitative MRI (qMRI) promises better specificity, accuracy, repeatability, and reproducibility relative to its clinically-used qualitative MRI counterpart. Longitudinal reproducibility is particularly important in qMRI. The goal is to reliably quantify tissue properties that may be assessed in longitudinal clinical studies throughout disease progression or during treatment. In this work, we present the initial data release of the quantitative MRI portion of the Courtois project on neural modelling (CNeuroMod), where the brain and cervical spinal cord of six participants were scanned at regular intervals over the course of several years. This first release includes 3 years of data collection and up to 10 sessions per participant using quantitative MRI imaging protocols (T, magnetization transfer (MTR, MTsat), and diffusion). In the brain, T , fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD) all exhibited high longitudinal reproducibility (intraclass correlation coefficient - ICC ≃ 1 and within-subject coefficient of variations - wCV < 1%). The spinal cord cross-sectional area (CSA) computed using T2w images and T exhibited the best longitudinal reproducibility (ICC ≃ 1 and 0.7 respectively, and wCV 2.4% and 6.9%). Results from this work show the level of longitudinal reproducibility that can be expected from qMRI protocols in the brain and spinal cord in the absence of hardware and software upgrades, and could help in the design of future longitudinal clinical studies.
与临床使用的定性磁共振成像（MRI）相比，定量MRI（qMRI）具有更高的特异性、准确性、可重复性和再现性。纵向再现性在qMRI中尤为重要。目标是可靠地量化在疾病进展或治疗期间的纵向临床研究中可评估的组织特性。在这项工作中，我们展示了库尔图瓦神经建模项目（CNeuroMod）定量MRI部分的初始数据发布，其中六名参与者的大脑和颈脊髓在数年时间里定期进行扫描。首次发布的数据包括3年的数据收集，每位参与者使用定量MRI成像协议（T1、磁化传递（MTR、MTsat）和扩散）进行多达10次扫描。在大脑中，T1、分数各向异性（FA）、平均扩散率（MD）和径向扩散率（RD）均表现出高度的纵向再现性（组内相关系数 - ICC ≃ 1，受试者内变异系数 - wCV < 1%）。使用T2加权图像计算的脊髓横截面积（CSA）和T1表现出最佳的纵向再现性（ICC分别为≃ 1和0.7，wCV分别为2.4%和6.9%）。这项工作的结果显示了在没有硬件和软件升级的情况下，大脑和脊髓中qMRI协议可预期的纵向再现性水平，并有助于未来纵向临床研究的设计。
