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一名HIV阳性患者并发肺曲霉病和隐球菌性脑膜炎：病例报告

Co-Infection of Pulmonary Aspergillosis and Cryptococcal Meningitis in an HIV-Positive Patient: A Case Report.

作者信息

Hemmatian Marjan, Khodavaisy Sadegh, Kazemizadeh Hossein, Jahanbin Behnaz, Ershadi Reza, Moradi Maryam, Salehi Mohammadreza, Xu Jianping, Hitchcock Megan, Ahmadikia Kazem, Ahmadi Ali, Manshadi Seyed Ali Dehghan

机构信息

Department of Infectious Diseases and Tropical Medicine, Iranian Research Center HIV/AIDS (IRCHA), Tehran University of Medical Science, Tehran, Iran.

Department of Medical Parasitology and Mycology, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Case Rep Infect Dis. 2025 Aug 5;2025:5630156. doi: 10.1155/crdi/5630156. eCollection 2025.

DOI:10.1155/crdi/5630156
PMID:40801018
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12343162/
Abstract

Opportunistic fungal infections (OFIs) are common among human immunodeficiency virus (HIV) -positive patients, especially in those with delayed diagnosis and treatment. Patients with severe HIV/AIDS with clusters of differentiation 4 (CD4) counts less than 100 are significantly prone to develop multiple OFIs. In the current study, we present a case of co-infection of pulmonary aspergillosis and cryptococcal meningitis in a late-diagnosed HIV patient with a low CD4 count.

摘要

机会性真菌感染（OFIs）在人类免疫缺陷病毒（HIV）阳性患者中很常见，尤其是在那些诊断和治疗延迟的患者中。严重HIV/AIDS且分化簇4（CD4）计数低于100的患者显著易于发生多种机会性真菌感染。在本研究中，我们报告了1例CD4计数低且诊断延迟的HIV患者合并肺曲霉病和隐球菌性脑膜炎感染的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2381/12343162/832d8b66adce/CRIID2025-5630156.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2381/12343162/162c7089f88b/CRIID2025-5630156.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2381/12343162/98e4cefd48db/CRIID2025-5630156.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2381/12343162/2113ed0ff13a/CRIID2025-5630156.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2381/12343162/832d8b66adce/CRIID2025-5630156.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2381/12343162/162c7089f88b/CRIID2025-5630156.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2381/12343162/98e4cefd48db/CRIID2025-5630156.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2381/12343162/2113ed0ff13a/CRIID2025-5630156.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2381/12343162/832d8b66adce/CRIID2025-5630156.004.jpg

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本文引用的文献

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Cryptococcal Meningitis: Differences between Patients with and without HIV-Infection.隐球菌性脑膜炎：HIV感染患者与未感染患者之间的差异
Pathogens. 2023 Mar 8;12(3):427. doi: 10.3390/pathogens12030427.
2
Analyses of the Global Multilocus Genotypes of the Human Pathogenic Yeast Species Complex.全球人类病原性酵母种复合体的多位点基因型分析。
Genes (Basel). 2022 Nov 6;13(11):2045. doi: 10.3390/genes13112045.
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Quantifying Deaths from Aspergillosis in HIV Positive People.量化艾滋病毒阳性人群中的曲霉病死亡人数。
J Fungi (Basel). 2022 Oct 27;8(11):1131. doi: 10.3390/jof8111131.
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Molecular Markers Reveal Epidemiological Patterns and Evolutionary Histories of the Human Pathogenic .分子标记揭示人类病原体的流行病学模式和进化史。
Front Cell Infect Microbiol. 2021 May 6;11:683670. doi: 10.3389/fcimb.2021.683670. eCollection 2021.
5
Treatment for HIV-associated cryptococcal meningitis.人类免疫缺陷病毒相关隐球菌性脑膜炎的治疗
Cochrane Database Syst Rev. 2018 Jul 25;7(7):CD005647. doi: 10.1002/14651858.CD005647.pub3.
6
Fungal infections in HIV/AIDS.HIV/AIDS 中的真菌感染。
Lancet Infect Dis. 2017 Nov;17(11):e334-e343. doi: 10.1016/S1473-3099(17)30303-1. Epub 2017 Jul 31.
7
Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis.HIV 相关隐球菌性脑膜炎的全球疾病负担：最新分析
Lancet Infect Dis. 2017 Aug;17(8):873-881. doi: 10.1016/S1473-3099(17)30243-8. Epub 2017 May 5.
8
Multiple opportunistic fungal infections in an individual with severe HIV disease: A case report.一名患有严重艾滋病的个体发生多种机会性真菌感染：病例报告。
Rev Iberoam Micol. 2016 Apr-Jun;33(2):118-21. doi: 10.1016/j.riam.2015.09.001. Epub 2016 Feb 17.
9
Global Molecular Epidemiology of Cryptococcus neoformans and Cryptococcus gattii: An Atlas of the Molecular Types.新型隐球菌和格特隐球菌的全球分子流行病学：分子类型图谱
Scientifica (Cairo). 2013;2013:675213. doi: 10.1155/2013/675213. Epub 2013 Jan 9.
10
Cryptococcosis.隐球菌病。
Clin Dermatol. 2012 Nov-Dec;30(6):599-609. doi: 10.1016/j.clindermatol.2012.01.005.