Jambart Isabelle, Wakim Anne-Marie, Cheaib Nadine, Lahoud Christelle, Mansour Maryam, Issa Carla Bou, Daoud Charbel, Moussa Lina Menassa, Gannagé-Yared Marie-Hélène, El Ghorayeb Nada
Department of Endocrinology at Hôtel-Dieu de France Hospital, Faculty of Medicine, Saint-Joseph University, Beirut, Lebanon.
Department of Radiology at Hôtel-Dieu de France Hospital, Faculty of Medicine, Saint-Joseph University, Beirut, Lebanon.
Front Endocrinol (Lausanne). 2025 Jul 29;16:1598685. doi: 10.3389/fendo.2025.1598685. eCollection 2025.
Adrenal incidentalomas (AI) are being more frequently reported with the advent of medical imaging. Studies on their prevalence, characteristics and functional status are lacking in the Middle East.
To determine the prevalence of AI as well as their clinical and radiological characteristics and referral rates to endocrinologists for hormonal testing.
We prospectively evaluated unselected adult patients who underwent an abdominal computed tomography (CT) between November 2022 and June 2023 at a Lebanese tertiary teaching hospital. An experienced radiologist carefully reviewed 4,464 CT. Patients with known or suspected malignancy or adrenal disease were excluded. Main outcome measures included prevalence of AI and referral rates to endocrinologists during a one-year follow-up.
3168 CT were retained for analysis, 222 had an AI, with an overall prevalence of 7%. There was no significant difference in prevalence according to gender (8% in women, 6% in men p = .06.). The prevalence increased with age from 0.9% in young adults (18-30 years) to 10.8% in patients older than 70. Mean age of patients with AI was 69 ± 14 years. 46% were males. Median size of AI was 1.7 cm (1.2-2.5). 45% had a density <10 Hounsfield Unit (HU) and 17% were bilateral. Patients with an AI were significantly older (p <.0001), had a higher Body mass index (BMI) (p = .0021), more hypertension (p = .023), dyslipidemia (p = .002), and cardiovascular diseases (CVD) (p = .0056). No difference according to sex was noted. The referral rate of AI to endocrinologists was only 5.4%.
The prevalence of AI in Lebanon is comparable to the worldwide prevalence and is linked to age, BMI, hypertension, dyslipidemia and CVD but not to gender. Despite this high prevalence, the rate of referral for appropriate investigations is poor. Raising awareness among clinicians is therefore essential for a better evaluation of these patients.
随着医学成像技术的出现，肾上腺偶发瘤（AI）的报告越来越频繁。中东地区缺乏关于其患病率、特征和功能状态的研究。
确定肾上腺偶发瘤的患病率及其临床和放射学特征，以及转诊至内分泌科进行激素检测的比例。
我们前瞻性评估了2022年11月至2023年6月在黎巴嫩一家三级教学医院接受腹部计算机断层扫描（CT）的未经过筛选的成年患者。一位经验丰富的放射科医生仔细审查了4464份CT扫描。已知或疑似患有恶性肿瘤或肾上腺疾病的患者被排除。主要观察指标包括肾上腺偶发瘤的患病率以及在一年随访期间转诊至内分泌科的比例。
保留3168份CT扫描用于分析，其中222例有肾上腺偶发瘤，总体患病率为7%。根据性别，患病率无显著差异（女性为8%，男性为6%，p = 0.06）。患病率随年龄增长而增加，从年轻人（18 - 30岁）的0.9%增至70岁以上患者的10.8%。肾上腺偶发瘤患者的平均年龄为69±14岁。46%为男性。肾上腺偶发瘤的中位大小为1.7厘米（1.2 - 2.5）。45%的密度<10亨氏单位（HU），17%为双侧。肾上腺偶发瘤患者年龄显著更大（p < 0.0001），体重指数（BMI）更高（p = 0.0021），高血压更多（p = 0.023），血脂异常更多（p = 0.002），心血管疾病（CVD）更多（p = 0.0056）。未观察到性别差异。肾上腺偶发瘤转诊至内分泌科的比例仅为5.4%。
黎巴嫩肾上腺偶发瘤的患病率与全球患病率相当，且与年龄、BMI、高血压、血脂异常和心血管疾病相关，但与性别无关。尽管患病率较高，但进行适当检查的转诊率较低。因此，提高临床医生的认识对于更好地评估这些患者至关重要。
