Fu Xueyuan, Wang Changwei, Yang Zhaoxia, Yu Junhong, Wang Jianfeng, Cao Wanxiu, Liu Chuyi, Yin Hua, Li Bafang, Feng Xiaomei, Du Fen, Hou Hu
Qingdao Marine Biomedical Research Institute Qingdao China.
State Key Laboratory of Biological Fermentation Engineering of Beer Tsingtao Brewery Co., Ltd Qingdao China.
Food Sci Nutr. 2025 Aug 11;13(8):e70678. doi: 10.1002/fsn3.70678. eCollection 2025 Aug.
The process of aging is a multifaceted physiological phenomenon that entails the gradual deterioration of physical health. In recent years, fermented foods have garnered significant attention for their potential anti-aging benefits; however, the effects of moderate consumption of beer on aging-related metabolic disorders remain unexplored. Original beer, India Pale Ale (IPA), and Stout are widely consumed alcoholic beverages on a global scale. The objective of this study is to investigate and compare the effect of moderate consumption of these beers on aging-related metabolic disorders in mice induced by D-galactose (D-gal), encompassing inflammation, organ impairment, oxidative stress, and dyslipidemia. Furthermore, potential mechanisms were elucidated through analysis of gut microbiota. Compared to the Original beer, oral administration of IPA and Stout effectively improved liver and kidney health in mice. All beers mitigated serum oxidative damage induced by D-gal, with Stout exhibiting a more significant effect. Additionally, the Original beer was more effective at restoring intestinal microbiota diversity. Moreover, the tested beers elicited modifications in the composition of intestinal microbiota, including a decline in Firmicutes abundance and an elevation in Bacteroidota levels, accompanied by a decrease in harmful bacteria like Deferribacterota and an increase in beneficial bacteria like and . The research findings suggest that moderate consumption of Original beer, IPA, and Stout possesses the potential to mitigate D-gal-induced metabolic disorders through modulation of gut microbiota dysbiosis. Consequently, these results provide valuable insights into the favorable impacts associated with moderate beer consumption on human aging and health.
衰老过程是一种多方面的生理现象，会导致身体健康逐渐恶化。近年来，发酵食品因其潜在的抗衰老益处而备受关注；然而，适度饮用啤酒对与衰老相关的代谢紊乱的影响仍未得到探索。原浆啤酒、印度淡色艾尔啤酒（IPA）和烈性黑啤酒是全球广泛消费的酒精饮料。本研究的目的是调查和比较适度饮用这些啤酒对D-半乳糖（D-gal）诱导的小鼠衰老相关代谢紊乱的影响，包括炎症、器官损伤、氧化应激和血脂异常。此外，通过分析肠道微生物群阐明了潜在机制。与原浆啤酒相比，口服IPA和烈性黑啤酒可有效改善小鼠的肝脏和肾脏健康。所有啤酒都减轻了D-gal诱导的血清氧化损伤，烈性黑啤酒的效果更显著。此外，原浆啤酒在恢复肠道微生物群多样性方面更有效。此外，受试啤酒引起了肠道微生物群组成的改变，包括厚壁菌门丰度下降和拟杆菌门水平升高，同时有害细菌如脱铁杆菌门减少，有益细菌如[此处原文缺失具体细菌名称]增加。研究结果表明，适度饮用原浆啤酒、IPA和烈性黑啤酒有可能通过调节肠道微生物群失调来减轻D-gal诱导的代谢紊乱。因此，这些结果为适度饮用啤酒对人类衰老和健康的有利影响提供了有价值的见解。
